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Literature summary for 4.2.1.1 extracted from

  • Innocenti, A.; Scozzafava, A.; Parkkila, S.; Puccetti, L.; De Simone, G.; Supuran, C.T.
    Investigations of the esterase, phosphatase, and sulfatase activities of the cytosolic mammalian carbonic anhydrase isoforms I, II, and XIII with 4-nitrophenyl esters as substrates (2008), Bioorg. Med. Chem. Lett., 18, 2267-2271.
    View publication on PubMed
Search for more literature for 4.2.1.1

Inhibitors

Inhibitors Comment Organism Structure
acetazolamide i.e. 5-acetamido-1,3,4-thiadiazole-2-sulfonamide Homo sapiens
acetazolamide i.e. 5-acetamido-1,3,4-thiadiazole-2-sulfonamide Mus musculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.935
-
 4-nitrophenyl phosphate isoform carbonic anhydrase I, at pH 7.4 and 25°C Homo sapiens
2.195
-
 4-nitrophenyl phosphate isoform carbonic anhydrase II, at pH 7.4 and 25°C Homo sapiens
3.025
-
 4-nitrophenyl acetate isoform carbonic anhydrase I, at pH 7.4 and 25°C Homo sapiens
4
-
 CO2 isoform carbonic anhydrase I, at pH 7.4 and 25°C Homo sapiens
9.3
-
 CO2 isoform carbonic anhydrase II, at pH 7.4 and 25°C Homo sapiens
13.8
-
 CO2 isoform carbonic anhydrase XIII, at pH 7.4 and 25°C Homo sapiens
19.3
-
 CO2 isoform carbonic anhydrase XIII, at pH 7.4 and 25°C Mus musculus
30.53
-
 4-nitrophenyl acetate isoform carbonic anhydrase II, at pH 7.4 and 25°C Homo sapiens
52
-
 CO2 isoform carbonic anhydrase III, at pH 7.4 and 25°C Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-nitrophenyl acetate + H2O
-
 Homo sapiens 4-nitrophenol + acetate
-
 ?
4-nitrophenyl phosphate + H2O
-
 Homo sapiens 4-nitrophenol + phosphate
-
 ?
4-nitrophenyl sulfate + H2O
-
 Homo sapiens 4-nitrophenol + sulfate
-
 ?
CO2 + H2O
-
 Mus musculus H2CO3
-
 r
CO2 + H2O
-
 Homo sapiens H2CO3
-
 r

Synonyms

Synonyms Comment Organism
alpha-CA
-
 Mus musculus
alpha-CA
-
 Homo sapiens
alpha-carbonic anhydrase
-
 Mus musculus
alpha-carbonic anhydrase
-
 Homo sapiens
CA I isoform Homo sapiens
CA II isoform Homo sapiens
CA XIII isoform Mus musculus
carbonic anhydrase I isoform Homo sapiens
carbonic anhydrase II isoform Homo sapiens
carbonic anhydrase XIII isoform Mus musculus

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
13000
-
 CO2 isoform carbonic anhydrase III, at pH 7.4 and 25°C Homo sapiens
83000
-
 CO2 isoform carbonic anhydrase XIII, at pH 7.4 and 25°C Mus musculus
150000
-
 CO2 isoform carbonic anhydrase XIII, at pH 7.4 and 25°C Homo sapiens
200000
-
 CO2 isoform carbonic anhydrase I, at pH 7.4 and 25°C Homo sapiens
1400000
-
 CO2 isoform carbonic anhydrase II, at pH 7.4 and 25°C Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0000263
-
 isoform carbonic anhydrase II, using 4-nitrophenyl phosphate as substrate, at pH 7.4 and 25°C Homo sapiens acetazolamide
0.000028
-
 isoform carbonic anhydrase II, using 4-nitrophenyl acetate as substrate, at pH 7.4 and 25°C Homo sapiens acetazolamide
0.00033
-
 isoform carbonic anhydrase I, using 4-nitrophenyl phosphate as substrate, at pH 7.4 and 25°C Homo sapiens acetazolamide
0.00049
-
 isoform carbonic anhydrase XIII, using 4-nitrophenyl acetate as substrate, at pH 7.4 and 25°C Mus musculus acetazolamide
0.00105
-
 isoform carbonic anhydrase XIII, using 4-nitrophenyl phosphate as substrate, at pH 7.4 and 25°C Mus musculus acetazolamide
0.00121
-
 isoform carbonic anhydrase I, using 4-nitrophenyl acetate as substrate, at pH 7.4 and 25°C Homo sapiens acetazolamide