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Literature summary for 4.2.1.1 extracted from

  • Nishimori, I.; Minakuchi, T.; Onishi, S.; Vullo, D.; Scozzafava, A.; Supuran, C.T.
    Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors (2007), J. Med. Chem., 50, 381-388.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
-
Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
2-aminobenzenesulfonamide
-
Homo sapiens
2-hydrazinobenzenesulfonamide
-
Homo sapiens
4-(2-aminoethyl)benzenesulfonamide
-
Homo sapiens
4-(2-hydroxyethyl)benzenesulfonamide
-
Homo sapiens
4-(aminomethyl)benzenesulfonamide
-
Homo sapiens
4-(aminosulfonyl)benzoic acid
-
Homo sapiens
4-(hydroxymethyl)benzenesulfonamide
-
Homo sapiens
4-amino-3-bromobenzenesulfonamide
-
Homo sapiens
4-amino-3-chlorobenzenesulfonamide
-
Homo sapiens
4-amino-3-fluorobenzenesulfonamide
-
Homo sapiens
4-amino-3-iodobenzenesulfonamide
-
Homo sapiens
4-amino-6-(trifluoromethyl)benzene-1,3-disulfonamide
-
Homo sapiens
4-amino-6-chlorobenzene-1,3-disulfonamide
-
Homo sapiens
4-amino-N-[4-(aminosulfonyl)benzyl]benzenesulfonamide
-
Homo sapiens
4-amino-N-{2-[4-(aminosulfonyl)phenyl]ethyl}benzenesulfonamide
-
Homo sapiens
4-Aminobenzenesulfonamide
-
Homo sapiens
4-hydrazinobenzenesulfonamide
-
Homo sapiens
4-methylbenzenesulfonamide
-
Homo sapiens
4-[(2-aminopyrimidin-4-yl)amino]benzenesulfonamide
-
Homo sapiens
5-(2-chlorophenyl)-1,3,4-thiadiazole-2-sulfonamide
-
Homo sapiens
5-amino-1,3,4-thiadiazole-2-sulfonamide
-
Homo sapiens
5-imino-4-methyl-4,5-dihydro-1,3,4-thiadiazole-2-sulfonamide
-
Homo sapiens
5-{[(4-aminophenyl)sulfonyl]amino}-1,3,4-thiadiazole-2-sulfonamide
-
Homo sapiens
6-hydroxy-1,3-benzothiazole-2-sulfonamide
-
Homo sapiens
acetazolamide
-
Homo sapiens
benzolamide
-
Homo sapiens
brinzolamide
-
Homo sapiens
dichlorophenamide
-
Homo sapiens
dorzolamide
-
Homo sapiens
ethoxzolamide
-
Homo sapiens
indisulam
-
Homo sapiens
methazolamide
-
Homo sapiens
sulpiride
-
Homo sapiens
topiramate
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P23280
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CO2 + H2O
-
Homo sapiens H2CO3
-
?

Synonyms

Synonyms Comment Organism
CA-VI
-
Homo sapiens
Carbonate dehydratase VI
-
Homo sapiens
carbonic anhydrase VI
-
Homo sapiens
hCA VI
-
Homo sapiens
Salivary carbonic anhydrase
-
Homo sapiens
Secreted carbonic anhydrase
-
Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0000008
-
sulpiride 20°C, pH 7.5, full-length recombinant hCA VI Homo sapiens
0.0000009
-
brinzolamide 20°C, pH 7.5, full-length recombinant hCA VI Homo sapiens
0.00001
-
methazolamide 20°C, pH 7.5, full-length recombinant hCA VI Homo sapiens
0.00001
-
dorzolamide 20°C, pH 7.5, full-length recombinant hCA VI Homo sapiens
0.000011
-
acetazolamide 20°C, pH 7.5, full-length recombinant hCA VI Homo sapiens
0.000024
-
4-amino-N-[2-[4-(aminosulfonyl)phenyl]ethyl]benzenesulfonamide 20°C, pH 7.5, full-length recombinant hCA VI Homo sapiens
0.000043
-
ethoxzolamide 20°C, pH 7.5, full-length recombinant hCA VI Homo sapiens
0.000045
-
topiramate 20°C, pH 7.5, full-length recombinant hCA VI Homo sapiens
0.000047
-
indisulam 20°C, pH 7.5, full-length recombinant hCA VI Homo sapiens
0.000055
-
4-amino-N-[4-(aminosulfonyl)benzyl]benzenesulfonamide 20°C, pH 7.5, full-length recombinant hCA VI Homo sapiens
0.000073
-
5-[[(4-aminophenyl)sulfonyl]amino]-1,3,4-thiadiazole-2-sulfonamide 20°C, pH 7.5, full-length recombinant hCA VI Homo sapiens
0.000079
-
dichlorophenamide 20°C, pH 7.5, full-length recombinant hCA VI Homo sapiens
0.000086
-
4-[(2-aminopyrimidin-4-yl)amino]benzenesulfonamide 20°C, pH 7.5, full-length recombinant hCA VI Homo sapiens
0.000093
-
benzolamide 20°C, pH 7.5, full-length recombinant hCA VI Homo sapiens
0.000096
-
4-amino-3-fluorobenzenesulfonamide 20°C, pH 7.5, full-length recombinant hCA VI Homo sapiens
0.000103
-
6-hydroxy-1,3-benzothiazole-2-sulfonamide 20°C, pH 7.5, full-length recombinant hCA VI Homo sapiens
0.000114
-
5-(2-chlorophenyl)-1,3,4-thiadiazole-2-sulfonamide 20°C, pH 7.5, full-length recombinant hCA VI Homo sapiens
0.000608
-
4-amino-6-chlorobenzene-1,3-disulfonamide 20°C, pH 7.5, full-length recombinant hCA VI Homo sapiens
0.00074
-
5-imino-4-methyl-4,5-dihydro-1,3,4-thiadiazole-2-sulfonamide 20°C, pH 7.5, full-length recombinant hCA VI Homo sapiens
0.000772
-
2-aminobenzenesulfonamide 20°C, pH 7.5, full-length recombinant hCA VI Homo sapiens
0.000798
-
5-amino-1,3,4-thiadiazole-2-sulfonamide 20°C, pH 7.5, full-length recombinant hCA VI Homo sapiens
0.000813
-
4-(2-aminoethyl)benzenesulfonamide 20°C, pH 7.5, full-length recombinant hCA VI Homo sapiens
0.000887
-
4-(aminosulfonyl)benzoic acid 20°C, pH 7.5, full-length recombinant hCA VI Homo sapiens
0.000941
-
4-Aminobenzenesulfonamide 20°C, pH 7.5, full-length recombinant hCA VI Homo sapiens
0.000955
-
4-amino-6-(trifluoromethyl)benzene-1,3-disulfonamide 20°C, pH 7.5, full-length recombinant hCA VI Homo sapiens
0.001024
-
4-amino-3-iodobenzenesulfonamide 20°C, pH 7.5, full-length recombinant hCA VI Homo sapiens
0.00109
-
2-hydrazinobenzenesulfonamide 20°C, pH 7.5, full-length recombinant hCA VI Homo sapiens
0.001097
-
4-amino-3-chlorobenzenesulfonamide 20°C, pH 7.5, full-length recombinant hCA VI Homo sapiens
0.001275
-
4-hydrazinobenzenesulfonamide 20°C, pH 7.5, full-length recombinant hCA VI Homo sapiens
0.001582
-
4-methylbenzenesulfonamide 20°C, pH 7.5, full-length recombinant hCA VI Homo sapiens
0.00415
-
4-(2-hydroxyethyl)benzenesulfonamide 20°C, pH 7.5, full-length recombinant hCA VI Homo sapiens
0.00468
-
4-amino-3-bromobenzenesulfonamide 20°C, pH 7.5, full-length recombinant hCA VI Homo sapiens
0.0048
-
4-(aminomethyl)benzenesulfonamide 20°C, pH 7.5, full-length recombinant hCA VI Homo sapiens
0.00668
-
4-(hydroxymethyl)benzenesulfonamide 20°C, pH 7.5, full-length recombinant hCA VI Homo sapiens