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Literature summary for 4.2.1.1 extracted from

  • Temperini, C.; Cecchi, A.; Boyle, N.A.; Scozzafava, A.; Cabeza, J.E.; Wentworth, P.; Blackburn, G.M.; Supuran, C.T.
    Carbonic anhydrase inhibitors. Interaction of 2-N,N-dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide with 12 mammalian isoforms: Kinetic and X-ray crystallographic studies (2007), Bioorg. Med. Chem. Lett., 18, 999-1005.
    View publication on PubMed
Search for more literature for 4.2.1.1

Crystallization (Commentary)

Crystallization (Comment) Organism
crystal structure of the hCA II/2-N,N-dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide adduct Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
2-N,N-dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide isoenzyme hCA I; isoenzyme hCA II; isoenzyme hCA III; isoenzyme hCA IV; isoenzyme hCA IX; isoenzyme hCA VA; isoenzyme hCA VB; isoenzyme hCA VI; isoenzyme hCA VII; isoenzyme hCA XII; isoenzyme hCA XIV Homo sapiens
2-N,N-dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide isoenzyme mCA XIII Mus musculus

Organism

Organism UniProt Comment Textmining
Homo sapiens O43570
-
-
Homo sapiens P00915
-
-
Homo sapiens P00918
-
-
Homo sapiens P07451
-
-
Homo sapiens P22748
-
-
Homo sapiens P23280
-
-
Homo sapiens P35218
-
-
Homo sapiens P43166
-
-
Homo sapiens Q16790
-
-
Homo sapiens Q9ULX7
-
-
Homo sapiens Q9Y2D0
-
-
Mus musculus Q9D6N1
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CO2 + H2O
-
 Homo sapiens H2CO3
-
 ?
CO2 + H2O
-
 Mus musculus H2CO3
-
 ?

Synonyms

Synonyms Comment Organism
hCA I
-
 Homo sapiens
HCA II
-
 Homo sapiens
hCA III
-
 Homo sapiens
hCA IV
-
 Homo sapiens
hCA IX
-
 Homo sapiens
hCA VA
-
 Homo sapiens
hCA VB
-
 Homo sapiens
hCA VI
-
 Homo sapiens
hCA VII
-
 Homo sapiens
hCA XII
-
 Homo sapiens
hCA XIV
-
 Homo sapiens
mCA XIII
-
 Mus musculus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00000061
-
 2-N,N-dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide isoenzyme hCA VII Homo sapiens
0.0000077
-
 2-N,N-dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide isoenzyme hCA XII Homo sapiens
0.0000171
-
 2-N,N-dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide isoenzyme hCA II Homo sapiens
0.00002
-
 2-N,N-dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide isoenzyme mCA XIII Mus musculus
0.0000235
-
 2-N,N-dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide isoenzyme hCA IV Homo sapiens
0.000039
-
 2-N,N-dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide isoenzyme hCA IX Homo sapiens
0.000121
-
 2-N,N-dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide isoenzyme hCA I Homo sapiens
0.000438
-
 2-N,N-dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide isoenzyme hCA VA Homo sapiens
0.001422
-
 2-N,N-dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide isoenzyme hCA VB Homo sapiens
0.00215
-
 2-N,N-dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide isoenzyme hCA VI Homo sapiens
0.0029
-
 2-N,N-dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide isoenzyme hCA XIV Homo sapiens
0.36
-
 2-N,N-dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide isoenzyme hCA III Homo sapiens