Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 4.2.1.1 extracted from

  • Nishimori, I.; Minakuchi, T.; Onishi, S.; Vullo, D.; Cecchi, A.; Scozzafava, A.; Supuran, C.T.
    Carbonic anhydrase inhibitors: cloning, characterization, and inhibition studies of the cytosolic isozyme III with sulfonamides (2007), Bioorg. Med. Chem., 15, 7229-7236.
    View publication on PubMed
Search for more literature for 4.2.1.1

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
2-aminobenzenesulfonamide
-
 Homo sapiens
2-hydrazinobenzenesulfonamide
-
 Homo sapiens
4-(2-aminoethyl)benzenesulfonamide
-
 Homo sapiens
4-(2-hydroxyethyl)benzenesulfonamide
-
 Homo sapiens
4-(aminomethyl)benzenesulfonamide
-
 Homo sapiens
4-(aminosulfonyl)-N-{2-[4-(aminosulfonyl)phenyl]ethyl}benzamide
-
 Homo sapiens
4-(aminosulfonyl)benzoic acid
-
 Homo sapiens
4-(hydroxymethyl)benzenesulfonamide
-
 Homo sapiens
4-amino-3,5-dibromobenzenesulfonamide
-
 Homo sapiens
4-amino-3-chlorobenzenesulfonamide
-
 Homo sapiens
4-amino-3-fluoro-5-iodobenzenesulfonamide
-
 Homo sapiens
4-amino-3-fluorobenzenesulfonamide
-
 Homo sapiens
4-amino-6-(trifluoromethyl)benzene-1,3-disulfonamide
-
 Homo sapiens
4-amino-6-chlorobenzene-1,3-disulfonamide
-
 Homo sapiens
4-amino-N-[4-(aminosulfonyl)benzyl]benzenesulfonamide
-
 Homo sapiens
4-amino-N-{2-[4-(aminosulfonyl)phenyl]ethyl}benzenesulfonamide
-
 Homo sapiens
4-Aminobenzenesulfonamide
-
 Homo sapiens
4-methylbenzenesulfonamide
-
 Homo sapiens
4-[(2-aminopyrimidin-4-yl)amino]benzenesulfonamide
-
 Homo sapiens
5-(2-chlorophenyl)-1,3,4-thiadiazole-2-sulfonamide
-
 Homo sapiens
5-acetamido-1,3,4-thiadiazole-2-sulfonamide
-
 Homo sapiens
5-amino-1,3,4-thiadiazole-2-sulfonamide
-
 Homo sapiens
5-imino-4-methyl-4,5-dihydro-1,3,4-thiadiazole-2-sulfonamide
-
 Homo sapiens
5-{[(4-amino-3-chloro-5-fluorophenyl)sulfonyl]amino}-1,3,4-thiadiazole-2-sulfonamide
-
 Homo sapiens
5-{[(4-aminophenyl)sulfonyl]amino}-1,3,4-thiadiazole-2-sulfonamide
-
 Homo sapiens
benzolamide
-
 Homo sapiens
brinzolamide
-
 Homo sapiens
celecoxib
-
 Homo sapiens
dichlorophenamide
-
 Homo sapiens
dorzolamide
-
 Homo sapiens
ethoxzolamide
-
 Homo sapiens
methazolamide
-
 Homo sapiens
prontosil
-
 Homo sapiens
saccharin
-
 Homo sapiens
sulpiride
-
 Homo sapiens
topiramate
-
 Homo sapiens
valdecoxib
-
 Homo sapiens
zonisamide
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-

Organism

Organism UniProt Comment Textmining
Homo sapiens P07451
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
pancreas
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CO2 + H2O
-
 Homo sapiens H2CO3
-
 ?

Synonyms

Synonyms Comment Organism
CA-III
-
 Homo sapiens
carbonate dehydratase III
-
 Homo sapiens
carbonic anhydrase 3
-
 Homo sapiens
carbonic anhydrase III
-
 Homo sapiens
hCA III
-
 Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0079
-
 4-methylbenzenesulfonamide 20°C, pH 7.5 Homo sapiens
0.0097
-
 4-amino-6-chlorobenzene-1,3-disulfonamide 20°C, pH 7.5 Homo sapiens
0.0104
-
 sulpiride 20°C, pH 7.5 Homo sapiens
0.0106
-
 topiramate 20°C, pH 7.5 Homo sapiens
0.0107
-
 4-amino-3,5-dibromobenzenesulfonamide 20°C, pH 7.5 Homo sapiens
0.0113
-
 4-(aminosulfonyl)benzoic acid 20°C, pH 7.5 Homo sapiens
0.0143
-
 benzolamide 20°C, pH 7.5 Homo sapiens
0.0146
-
 5-(2-chlorophenyl)-1,3,4-thiadiazole-2-sulfonamide 20°C, pH 7.5 Homo sapiens
0.0181
-
 5-[[(4-aminophenyl)sulfonyl]amino]-1,3,4-thiadiazole-2-sulfonamide 20°C, pH 7.5 Homo sapiens
0.019
-
 4-amino-3-fluoro-5-iodobenzenesulfonamide 20°C, pH 7.5 Homo sapiens
0.0805
-
 5-[[(4-amino-3-chloro-5-fluorophenyl)sulfonyl]amino]-1,3,4-thiadiazole-2-sulfonamide 20°C, pH 7.5 Homo sapiens
0.11
-
 brinzolamide 20°C, pH 7.5 Homo sapiens
0.114
-
 4-amino-N-[4-(aminosulfonyl)benzyl]benzenesulfonamide 20°C, pH 7.5 Homo sapiens
0.14
-
 4-amino-N-[2-[4-(aminosulfonyl)phenyl]ethyl]benzenesulfonamide 20°C, pH 7.5 Homo sapiens
0.148
-
 5-amino-1,3,4-thiadiazole-2-sulfonamide 20°C, pH 7.5 Homo sapiens
0.154
-
 valdecoxib 20°C, pH 7.5 Homo sapiens
0.198
-
 5-imino-4-methyl-4,5-dihydro-1,3,4-thiadiazole-2-sulfonamide 20°C, pH 7.5 Homo sapiens
0.236
-
 5-acetamido-1,3,4-thiadiazole-2-sulfonamide 20°C, pH 7.5 Homo sapiens
0.681
-
 4-(aminomethyl)benzenesulfonamide 20°C, pH 7.5 Homo sapiens
0.684
-
 dichlorophenamide 20°C, pH 7.5 Homo sapiens
0.71
-
 4-amino-3-chlorobenzenesulfonamide 20°C, pH 7.5 Homo sapiens
0.77
-
 methazolamide 20°C, pH 7.5 Homo sapiens
0.77
-
 dorzolamide 20°C, pH 7.5 Homo sapiens
0.78
-
 zonisamide 20°C, pH 7.5 Homo sapiens
0.788
-
 prontosil 20°C, pH 7.5 Homo sapiens
0.887
-
 2-aminobenzenesulfonamide 20°C, pH 7.5 Homo sapiens
0.988
-
 4-Aminobenzenesulfonamide 20°C, pH 7.5 Homo sapiens
1
-
 celecoxib 20°C, pH 7.5 Homo sapiens
1.06
-
 4-(aminosulfonyl)-N-[2-[4-(aminosulfonyl)phenyl]ethyl]benzamide 20°C, pH 7.5 Homo sapiens
1.113
-
 ethoxzolamide 20°C, pH 7.5 Homo sapiens
1.187
-
 4-(2-hydroxyethyl)benzenesulfonamide 20°C, pH 7.5 Homo sapiens
1.276
-
 4-amino-6-(trifluoromethyl)benzene-1,3-disulfonamide 20°C, pH 7.5 Homo sapiens
1.6
-
 4-(2-aminoethyl)benzenesulfonamide 20°C, pH 7.5 Homo sapiens
1.995
-
 2-hydrazinobenzenesulfonamide 20°C, pH 7.5 Homo sapiens
2.075
-
 4-amino-3-fluorobenzenesulfonamide 20°C, pH 7.5 Homo sapiens
2.2
-
 saccharin 20°C, pH 7.5 Homo sapiens
2.633
-
 4-[(2-aminopyrimidin-4-yl)amino]benzenesulfonamide 20°C, pH 7.5 Homo sapiens
4.89
-
 4-(hydroxymethyl)benzenesulfonamide 20°C, pH 7.5 Homo sapiens