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Literature summary for 4.2.1.1 extracted from

  • Premkumar, L.; Greenblatt, H.M.; Bageshwar, U.K.; Savchenko, T.; Gokhman, I.; Sussman, J.L.; Zamir, A.
    Three-dimensional structure of a halotolerant algal carbonic anhydrase predicts halotolerance of a mammalian homolog (2005), Proc. Natl. Acad. Sci. USA, 102, 7493-7498.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.2.1.1

Crystallization (Commentary)

Crystallization (Comment) Organism
crystal structure of dCA II at 1.86 A resolution, vapour diffusion method Dunaliella salina

General Stability

General Stability Organism
enzyme retains conformational stability in low and high salt concentrations Dunaliella salina

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
19.7
-
 H2CO3 without NaCl Homo sapiens
28.7
-
 H2CO3 without NaCl Dunaliella salina
30.1
-
 H2CO3 0.1 M NaCl Dunaliella salina
32.2
-
 H2CO3 0.25 M NaCl Dunaliella salina
33.4
-
 H2CO3 0.5 M NaCl Dunaliella salina
80.1
-
 H2CO3 0.1 M NaCl Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Dunaliella salina
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ monomer contains a single Zn2+ Dunaliella salina

Organism

Organism UniProt Comment Textmining
Dunaliella salina
-
-
-
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
H2CO3
-
 Homo sapiens CO2 + H2O
-
 ?
H2CO3
-
 Dunaliella salina CO2 + H2O
-
 ?

Subunits

Subunits Comment Organism
monomer
-
 Dunaliella salina

Synonyms

Synonyms Comment Organism
carbonic anhydrase I
-
 Homo sapiens
carbonic anhydrase II
-
 Dunaliella salina
dCA II
-
 Dunaliella salina
hCA I
-
 Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
28700
-
 H2CO3 0.1 M NaCl Homo sapiens
29500
-
 H2CO3 without NaCl Homo sapiens
38300
-
 H2CO3 without NaCl Dunaliella salina
39100
-
 H2CO3 0.5 M NaCl Dunaliella salina
41200
-
 H2CO3 0.25 M NaCl Dunaliella salina
44600
-
 H2CO3 0.1 M NaCl Dunaliella salina