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Literature summary for 4.2.1.1 extracted from

  • ึzensoy, O.; Nishimori, I.; Vullo, D.; Puccetti, L.; Scozzafava, A.; Supuran, C.T.
    Carbonic anhydrase inhibitors: inhibition of the human transmembrane isozyme XIV with a library of aromatic/heterocyclic sulfonamides (2005), Bioorg. Med. Chem., 13, 6089-6093.
    View publication on PubMed
Search for more literature for 4.2.1.1

Inhibitors

Inhibitors Comment Organism Structure
3-[(anilinocarbonyl)amino]benzenesulfonamide
-
 Homo sapiens
4-(aminosulfonyl)-N-[2-[4-(aminosulfonyl)phenyl]ethyl]benzamide
-
 Homo sapiens
4-aminoethylbenzenesulfonamide
-
 Homo sapiens
4-[(acetyloxy)amino]-N-[4-(aminosulfonyl)phenyl]benzenesulfonamide
-
 Homo sapiens
4-[(anilinocarbonyl)amino]-6-chlorobenzene-1,3-disulfonamide
-
 Homo sapiens
4-[(methylsulfonyl)amino]benzenesulfonamide
-
 Homo sapiens
4-[(phenylsulfonyl)amino]benzenesulfonamide
-
 Homo sapiens
4-[2-[(anilinocarbonothioyl)amino]ethyl]benzenesulfonamide
-
 Homo sapiens
4-[2-[(anilinocarbonyl)amino]ethyl]benzenesulfonamide
-
 Homo sapiens
4-[2-[([[4-(aminosulfonyl)phenyl]amino]carbonothioyl)amino]ethyl]benzenesulfonamide
-
 Homo sapiens
4-[[(anilinocarbonothioyl)amino]methyl]benzenesulfonamide
-
 Homo sapiens
4-[[(phenylsulfonyl)amino]methyl]benzenesulfonamide
-
 Homo sapiens
5-[[(4-bromophenyl)sulfonyl]amino]-1,3,4-thiadiazole-2-sulfonamide
-
 Homo sapiens
5-[[(4-nitrophenyl)sulfonyl]amino]-1,3,4-thiadiazole-2-sulfonamide
-
 Homo sapiens
acetazolamide
-
 Homo sapiens
ethoxzolamide
-
 Homo sapiens
homosulfanilamide
-
 Homo sapiens
N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)furan-2-carboxamide
-
 Homo sapiens
N-[4-(aminosulfonyl)phenyl]-2,2,2-trifluoroacetamide
-
 Homo sapiens
N-[4-(aminosulfonyl)phenyl]-2,2-dimethylpropanamide
-
 Homo sapiens
N-[4-(aminosulfonyl)phenyl]-2-methylpropanamide
-
 Homo sapiens
N-[4-(aminosulfonyl)phenyl]acetamide
-
 Homo sapiens
N-[4-(aminosulfonyl)phenyl]benzamide
-
 Homo sapiens
N-[4-(aminosulfonyl)phenyl]butanamide
-
 Homo sapiens
N-[4-(aminosulfonyl)phenyl]pentanamide
-
 Homo sapiens
N-[4-(aminosulfonyl)phenyl]propanamide
-
 Homo sapiens
sulfanilamide
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens O43570 recombinant
-
Homo sapiens Q16790 recombinant
-
Homo sapiens Q9ULX7 carbonic anhydrase 14 precursor; recombinant
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CO2 + H2O
-
 Homo sapiens H2CO3
-
 ?

Synonyms

Synonyms Comment Organism
CA XII
-
 Homo sapiens
carbonic anhydrase 14
-
 Homo sapiens
carbonic anhydrase IX
-
 Homo sapiens
carbonic anhydrase XII
-
 Homo sapiens
carbonic anhydrase XIV
-
 Homo sapiens
hCA IX
-
 Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0000003
-
 homosulfanilamide pH 7.5, catalytic domain of cloned isoenzyme Homo sapiens
0.0000019
-
 5-[[(4-nitrophenyl)sulfonyl]amino]-1,3,4-thiadiazole-2-sulfonamide pH 7.5, catalytic domain of cloned isoenzyme Homo sapiens
0.0000024
-
 N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)furan-2-carboxamide pH 7.5, catalytic domain of cloned isoenzyme Homo sapiens
0.000003
-
 4-[2-[([[4-(aminosulfonyl)phenyl]amino]carbonothioyl)amino]ethyl]benzenesulfonamide pH 7.5, catalytic domain of cloned isoenzyme Homo sapiens
0.0000032
-
 4-aminoethylbenzenesulfonamide pH 7.5, catalytic domain of cloned isoenzyme Homo sapiens
0.0000033
-
 5-[[(4-bromophenyl)sulfonyl]amino]-1,3,4-thiadiazole-2-sulfonamide pH 7.5, catalytic domain of cloned isoenzyme Homo sapiens
0.0000057
-
 acetazolamide pH 7.5, catalytic domain of cloned isoenzyme Homo sapiens
0.00001
-
 3-[(anilinocarbonyl)amino]benzenesulfonamide pH 7.5, catalytic domain of cloned isoenzyme Homo sapiens
0.00001
-
 5-[[(4-nitrophenyl)sulfonyl]amino]-1,3,4-thiadiazole-2-sulfonamide pH 7.5, full-length recombinant enzyme Homo sapiens
0.000012
-
 4-(aminosulfonyl)-N-[2-[4-(aminosulfonyl)phenyl]ethyl]benzamide pH 7.5, catalytic domain of cloned isoenzyme Homo sapiens
0.000013
-
 4-(aminosulfonyl)-N-[2-[4-(aminosulfonyl)phenyl]ethyl]benzamide pH 7.5, catalytic domain of cloned isoenzyme Homo sapiens
0.000013
-
 4-[2-[(anilinocarbonyl)amino]ethyl]benzenesulfonamide pH 7.5, catalytic domain of cloned isoenzyme Homo sapiens
0.000013
-
 N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)furan-2-carboxamide pH 7.5, catalytic domain of cloned isoenzyme Homo sapiens
0.000013
-
 5-[[(4-bromophenyl)sulfonyl]amino]-1,3,4-thiadiazole-2-sulfonamide pH 7.5, full-length recombinant enzyme Homo sapiens
0.000014
-
 3-[(anilinocarbonyl)amino]benzenesulfonamide pH 7.5, catalytic domain of cloned isoenzyme Homo sapiens
0.000016
-
 5-[[(4-nitrophenyl)sulfonyl]amino]-1,3,4-thiadiazole-2-sulfonamide pH 7.5, catalytic domain of cloned isoenzyme Homo sapiens
0.000018
-
 4-[[(anilinocarbonothioyl)amino]methyl]benzenesulfonamide pH 7.5, catalytic domain of cloned isoenzyme Homo sapiens
0.000018
-
 4-[2-[(anilinocarbonyl)amino]ethyl]benzenesulfonamide pH 7.5, catalytic domain of cloned isoenzyme Homo sapiens
0.000021
-
 N-[4-(aminosulfonyl)phenyl]benzamide pH 7.5, catalytic domain of cloned isoenzyme Homo sapiens
0.000021
-
 4-[2-[(anilinocarbonothioyl)amino]ethyl]benzenesulfonamide pH 7.5, catalytic domain of cloned isoenzyme Homo sapiens
0.000021
-
 5-[[(4-bromophenyl)sulfonyl]amino]-1,3,4-thiadiazole-2-sulfonamide pH 7.5, catalytic domain of cloned isoenzyme Homo sapiens
0.000022
-
 ethoxzolamide pH 7.5, catalytic domain of cloned isoenzyme Homo sapiens
0.000023
-
 N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)furan-2-carboxamide pH 7.5, full-length recombinant enzyme Homo sapiens
0.000024
-
 4-[2-[(anilinocarbonothioyl)amino]ethyl]benzenesulfonamide pH 7.5, catalytic domain of cloned isoenzyme Homo sapiens
0.000025
-
 acetazolamide pH 7.5, catalytic domain of cloned isoenzyme Homo sapiens
0.000025
-
 ethoxzolamide pH 7.5, full-length recombinant enzyme Homo sapiens
0.000026
-
 4-[[(anilinocarbonothioyl)amino]methyl]benzenesulfonamide pH 7.5, catalytic domain of cloned isoenzyme Homo sapiens
0.000031
-
 N-[4-(aminosulfonyl)phenyl]-2,2,2-trifluoroacetamide pH 7.5, catalytic domain of cloned isoenzyme Homo sapiens
0.000033
-
 4-[(methylsulfonyl)amino]benzenesulfonamide pH 7.5, catalytic domain of cloned isoenzyme Homo sapiens
0.000033
-
 4-aminoethylbenzenesulfonamide pH 7.5, catalytic domain of cloned isoenzyme Homo sapiens
0.000037
-
 sulfanilamide pH 7.5, catalytic domain of cloned isoenzyme Homo sapiens
0.000037
-
 4-[(acetyloxy)amino]-N-[4-(aminosulfonyl)phenyl]benzenesulfonamide pH 7.5, catalytic domain of cloned isoenzyme Homo sapiens
0.00004
-
 4-[[(phenylsulfonyl)amino]methyl]benzenesulfonamide pH 7.5, catalytic domain of cloned isoenzyme Homo sapiens
0.000041
-
 acetazolamide pH 7.5, full-length recombinant enzyme Homo sapiens
0.000049
-
 N-[4-(aminosulfonyl)phenyl]acetamide pH 7.5, catalytic domain of cloned isoenzyme Homo sapiens
0.00005
-
 ethoxzolamide pH 7.5, catalytic domain of cloned isoenzyme Homo sapiens
0.000052
-
 4-[(phenylsulfonyl)amino]benzenesulfonamide pH 7.5, catalytic domain of cloned isoenzyme Homo sapiens
0.000056
-
 N-[4-(aminosulfonyl)phenyl]propanamide pH 7.5, catalytic domain of cloned isoenzyme Homo sapiens
0.000068
-
 4-[(phenylsulfonyl)amino]benzenesulfonamide pH 7.5, catalytic domain of cloned isoenzyme Homo sapiens
0.000073
-
 N-[4-(aminosulfonyl)phenyl]benzamide pH 7.5, catalytic domain of cloned isoenzyme Homo sapiens
0.000076
-
 4-[(acetyloxy)amino]-N-[4-(aminosulfonyl)phenyl]benzenesulfonamide pH 7.5, catalytic domain of cloned isoenzyme Homo sapiens
0.000079
-
 N-[4-(aminosulfonyl)phenyl]pentanamide pH 7.5, catalytic domain of cloned isoenzyme Homo sapiens
0.000079
-
 4-[2-[([[4-(aminosulfonyl)phenyl]amino]carbonothioyl)amino]ethyl]benzenesulfonamide pH 7.5, catalytic domain of cloned isoenzyme Homo sapiens
0.000079
-
 4-(aminosulfonyl)-N-[2-[4-(aminosulfonyl)phenyl]ethyl]benzamide pH 7.5, full-length recombinant enzyme Homo sapiens
0.000083
-
 N-[4-(aminosulfonyl)phenyl]butanamide pH 7.5, catalytic domain of cloned isoenzyme Homo sapiens
0.000083
-
 4-[[(phenylsulfonyl)amino]methyl]benzenesulfonamide pH 7.5, catalytic domain of cloned isoenzyme Homo sapiens
0.000085
-
 N-[4-(aminosulfonyl)phenyl]butanamide pH 7.5, catalytic domain of cloned isoenzyme Homo sapiens
0.000085
-
 4-[2-[([[4-(aminosulfonyl)phenyl]amino]carbonothioyl)amino]ethyl]benzenesulfonamide pH 7.5, full-length recombinant enzyme Homo sapiens
0.000103
-
 homosulfanilamide pH 7.5, catalytic domain of cloned isoenzyme Homo sapiens
0.000106
-
 N-[4-(aminosulfonyl)phenyl]propanamide pH 7.5, catalytic domain of cloned isoenzyme Homo sapiens
0.000112
-
 N-[4-(aminosulfonyl)phenyl]-2,2,2-trifluoroacetamide pH 7.5, catalytic domain of cloned isoenzyme Homo sapiens
0.000113
-
 4-[(methylsulfonyl)amino]benzenesulfonamide pH 7.5, catalytic domain of cloned isoenzyme Homo sapiens
0.000135
-
 N-[4-(aminosulfonyl)phenyl]acetamide pH 7.5, catalytic domain of cloned isoenzyme Homo sapiens
0.000136
-
 N-[4-(aminosulfonyl)phenyl]-2,2-dimethylpropanamide pH 7.5, catalytic domain of cloned isoenzyme Homo sapiens
0.000138
-
 N-[4-(aminosulfonyl)phenyl]-2-methylpropanamide pH 7.5, catalytic domain of cloned isoenzyme Homo sapiens
0.000139
-
 N-[4-(aminosulfonyl)phenyl]-2-methylpropanamide pH 7.5, catalytic domain of cloned isoenzyme Homo sapiens
0.000146
-
 4-[(anilinocarbonyl)amino]-6-chlorobenzene-1,3-disulfonamide pH 7.5, catalytic domain of cloned isoenzyme Homo sapiens
0.000147
-
 N-[4-(aminosulfonyl)phenyl]pentanamide pH 7.5, catalytic domain of cloned isoenzyme Homo sapiens
0.000203
-
 4-[2-[(anilinocarbonothioyl)amino]ethyl]benzenesulfonamide pH 7.5, full-length recombinant enzyme Homo sapiens
0.000237
-
 4-[[(anilinocarbonothioyl)amino]methyl]benzenesulfonamide pH 7.5, full-length recombinant enzyme Homo sapiens
0.000249
-
 N-[4-(aminosulfonyl)phenyl]-2,2-dimethylpropanamide pH 7.5, catalytic domain of cloned isoenzyme Homo sapiens
0.00026
-
 4-[2-[(anilinocarbonyl)amino]ethyl]benzenesulfonamide pH 7.5, full-length recombinant enzyme Homo sapiens
0.000294
-
 sulfanilamide pH 7.5, catalytic domain of cloned isoenzyme Homo sapiens
0.000348
-
 4-[(anilinocarbonyl)amino]-6-chlorobenzene-1,3-disulfonamide pH 7.5, catalytic domain of cloned isoenzyme Homo sapiens
0.00043
-
 4-[(anilinocarbonyl)amino]-6-chlorobenzene-1,3-disulfonamide pH 7.5, full-length recombinant enzyme Homo sapiens
0.000465
-
 4-[[(phenylsulfonyl)amino]methyl]benzenesulfonamide pH 7.5, full-length recombinant enzyme Homo sapiens
0.00088
-
 4-[(acetyloxy)amino]-N-[4-(aminosulfonyl)phenyl]benzenesulfonamide pH 7.5, full-length recombinant enzyme Homo sapiens
0.000935
-
 4-[(phenylsulfonyl)amino]benzenesulfonamide pH 7.5, full-length recombinant enzyme Homo sapiens
0.00125
-
 4-[(methylsulfonyl)amino]benzenesulfonamide pH 7.5, full-length recombinant enzyme Homo sapiens
0.001345
-
 N-[4-(aminosulfonyl)phenyl]benzamide pH 7.5, full-length recombinant enzyme Homo sapiens
0.00143
-
 N-[4-(aminosulfonyl)phenyl]-2,2,2-trifluoroacetamide pH 7.5, full-length recombinant enzyme Homo sapiens
0.00145
-
 3-[(anilinocarbonyl)amino]benzenesulfonamide pH 7.5, full-length recombinant enzyme Homo sapiens
0.0023
-
 N-[4-(aminosulfonyl)phenyl]pentanamide pH 7.5, full-length recombinant enzyme Homo sapiens
0.00235
-
 N-[4-(aminosulfonyl)phenyl]butanamide pH 7.5, full-length recombinant enzyme Homo sapiens
0.0024
-
 N-[4-(aminosulfonyl)phenyl]-2-methylpropanamide pH 7.5, full-length recombinant enzyme Homo sapiens
0.00265
-
 N-[4-(aminosulfonyl)phenyl]-2,2-dimethylpropanamide pH 7.5, full-length recombinant enzyme Homo sapiens
0.0029
-
 4-aminoethylbenzenesulfonamide pH 7.5, full-length recombinant enzyme Homo sapiens
0.0032
-
 homosulfanilamide pH 7.5, full-length recombinant enzyme Homo sapiens
0.0037
-
 N-[4-(aminosulfonyl)phenyl]propanamide pH 7.5, full-length recombinant enzyme Homo sapiens
0.0042
-
 N-[4-(aminosulfonyl)phenyl]acetamide pH 7.5, full-length recombinant enzyme Homo sapiens
0.0054
-
 sulfanilamide pH 7.5, full-length recombinant enzyme Homo sapiens