Literature summary for 4.2.1.1 extracted from

Abbate, F.; Supuran, C.T.; Scozzafava, A.; Orioloi, P.; Stubbs, M.T.; Klebe, G.
Nonaromatic sulfonamide group as an ideal anchor or potent human carbonic anhydrase inhibitors: Role of hydrogen-bonding networks in ligand binding and drug design (2002), J. Med. Chem., 45, 3583-3587.

Search for more literature for 4.2.1.1

Application

Application	Comment	Organism
medicine	relevance for the drug design of novel CA inhibitors, intersting pharmacological applications	Homo sapiens

Crystallization (Commentary)

Crystallization (Comment)	Organism
crystals obtained by hanging drop technique, hCA II-sulfamate, space group P2(1), a : 42.32 A, b : 41.48 A, c : 72.44 A, hCA II-sulfamide, space group P2(1), a : 42.70 A, b : 41.70 A, c : 73.00 A	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
4-fluorobenzenesulfonamide	-	Homo sapiens
sulfamic acid	-	Homo sapiens
sulfamide	-	Homo sapiens

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Zn2+	zinc enzyme	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
H2CO3	Homo sapiens	-	CO2 + H2O	-	r

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P00918	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
H2CO3	-	Homo sapiens	CO2 + H2O	-	r

Synonyms

Synonyms	Comment	Organism
CA	-	Homo sapiens
carbonic anhydrase	-	Homo sapiens
HCA II	-	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)