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Literature summary for 4.2.1.1 extracted from

  • Chen, H.H.; Gross, S.; Liao, J.; MaLaughlin, M.; Dean, T.; Sly, W.S.; May, J.A.
    2H-thieno[3,2-e]- and [2,3-e-]-1,2-thiazine-6-sulfonamide 1,1-dioxides as ocular hypotensive agents: Synthesis, carbonic anhydrase inhibition and evaluation in the rabbit (2000), Bioorg. Med. Chem., 8, 957-975.
    View publication on PubMed
Search for more literature for 4.2.1.1

Inhibitors

Inhibitors Comment Organism Structure
1,3-dioxolan-2-yl-N-(2-propenyl)-2-thiophene-sulfonamide
-
 Homo sapiens
2-(1-methylethyl)-3-[(2-propynylamino)methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide
-
 Homo sapiens
2-(1-methylethyl)-3-[(4-morpholinyl)methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide
-
 Homo sapiens
2-(2-hydroxyethyl)-N-(1,1-dimethylethyl)-2H-thieno[3,2-e-]-1,2-thiazine-6-sulfonamide 1,1-dioxide
-
 Homo sapiens
2-(2-methoxyethyl)-3-[(4-morpholinyl)methyl]-2-(2-propenyl)-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide
-
 Homo sapiens
2-(2-methoxyethyl)-3-[[bis(2-methoxyethyl)amino]methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide hydrochloride
-
 Homo sapiens
2-(3,4-dimethoxyphenyl)-3-[(4-morpholinyl)methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide hydrochloride
-
 Homo sapiens
2-(3-hydroxyphenyl)-3-(4-morpholinylmethyl)-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide
-
 Homo sapiens
2-(3-hydroxyphenyl)-3-[(2-propynylamino)methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide hydrochloride
-
 Homo sapiens
2-(3-hydroxypropyl)-3-(4-morpholinylmethyl)-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide
-
 Homo sapiens
2-(3-methoxyphenyl)-3-[(2-hydroxyethylamino)methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide hydrochloride
-
 Homo sapiens
2-(3-methoxyphenyl)-3-[(4-morpholinyl)methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide hydrochloride
-
 Homo sapiens
2-(3-methoxypropyl)-3-[(4-morpholinyl)methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide
-
 Homo sapiens
2-(3-methoxypropyl)-3-[(4-morpholinyl)methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide hydrochloride
-
 Homo sapiens
2-cyclohexyl-3-[(4-morpholinyl)methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide
-
 Homo sapiens
2-cyclopropylmethyl-3-[(4-morpholinyl)methyl]-2-(2-propenyl)-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide
-
 Homo sapiens
2-ethyl-3-[(4-morpholinyl)methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide hydrochloride
-
 Homo sapiens
2-ethyl-3-[[bis(2-hydroxyethyl)amino]methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide hydrochloride
-
 Homo sapiens
2-ethyl-3-[[bis(2-methoxyethyl)amino]methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide hydrochloride
-
 Homo sapiens
2-methyl-2H-thieno[2,3-e]-1,2-thiazine-3-methanol 1,1-dioxide
-
 Homo sapiens
2-methyl-2H-thieno[3,2-e]-1,2-thiazine-3-methanol 1,1-dioxide
-
 Homo sapiens
2-methyl-3-(4-morpholinylmethyl)-2H-thieno[2,3-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide
-
 Homo sapiens
2-methyl-3-(4-morpholinylmethyl)-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide hydrochloride
-
 Homo sapiens
2-methyl-3-[(4-morpholinyl)methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide
-
 Homo sapiens
2-methyl-3-[[N-(2-methoxyethyl)-N-(2-propenyl)amino]methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide
-
 Homo sapiens
2-methyl-3-[[N-(2-methoxyethyl)-N-(3-methoxypropyl)-amino]methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide
-
 Homo sapiens
2-propyl-3-[(2-propynylamino)methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide
-
 Homo sapiens
2-[(4-methoxyphenyl)methyl]-3-[(4-morpholinyl)methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide
-
 Homo sapiens
2-[(4-methoxyphenyl)methyl]-3-[(4-morpholinyl)methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide hydrochloride
-
 Homo sapiens
2-[(4-morpholinyl)phenyl]-3-[(4-morpholinyl)methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide hydrochloride
-
 Homo sapiens
2-[2-(4-morpholinyl)ethyl]-2H-thieno[3,2-e-]-1,2-thiazine-6-sulfonamide 1,1-dioxide hydrochloride
-
 Homo sapiens
2-[2-(acetoxy)ethyl]-N-(1,1-dimethylethyl)-4-hydroxy-2H-thieno[3,2-e-]-1,2-thiazine-6-sulfonamide 1,1-dioxide
-
 Homo sapiens
2-[2-(propylamino)ethyl]-2H-thieno[3,2-e-]-1,2-thiazine-6-sulfonamide 1,1-dioxide hydrochloride
-
 Homo sapiens
2-[2-[4-acetyl-(1-piperazinyl)]ethyl]-2H-thieno[3,2-e-]-1,2-thiazine-6-sulfonamide 1,1-dioxide
-
 Homo sapiens
2-[2-[bis(2-methoxyethyl)amino]ethyl]-2H-thieno[3,2-e-]-1,2-thiazine-6-sulfonamide 1,1-dioxide hydrochloride
-
 Homo sapiens
2-[4-(4-morpholinyl)-2-butenyl]-2H-thieno[3,2-e-]-1,2-thiazine-6-sulfonamide 1,1-dioxide hydrochloride
-
 Homo sapiens
3,5-dibromo-2-(1,3-dioxalan-2-yl)-thiophene
-
 Homo sapiens
3-(1,3-dioxolan-2-yl)-N-(2-methoxyethyl)-2-thiophenesulfonamide
-
 Homo sapiens
3-(1,3-dioxolan-2-yl)-N-(3,4-dimethoxyphenyl)-2-thiophenesulfonamide
-
 Homo sapiens
3-(1,3-dioxolan-2-yl)-N-(3-methoxyphenyl)-2-thiophenesulfonamide
-
 Homo sapiens
3-(1,3-dioxolan-2-yl)-N-(4-(4-morpholinyl)phenyl)-2-thiophenesulfonamide
-
 Homo sapiens
3-(1,3-dioxolan-2-yl)-N-cyclohexyl-2-thiophenesulfonamide
-
 Homo sapiens
3-(1,3-dioxolan-2-yl)-N-[4-(4-morpholinyl)phenyl]-2-thiophenesulfonamide
-
 Homo sapiens
3-3-(1,3-dioxolan-2-yl)-N-(1-methylethyl)-2-thiophene-sulfonamide
-
 Homo sapiens
3-chloromethyl-N-(1,1-dimethylethyl)-2-(3-methoxyphenyl)-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide
-
 Homo sapiens
3-hydroxymethyl 2-methyl-2H-thieno[2,3-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide
-
 Homo sapiens
3-hydroxymethyl-2-methyl-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide
-
 Homo sapiens
3-[(1-imidazolyl)methyl]-2-(3-methoxypropyl)-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide
-
 Homo sapiens
3-[(4-morpholinyl)methyl]-2-(2-propenyl)-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide
-
 Homo sapiens
3-[(4-morpholinyl)methyl]-2-propyl-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide hydrochloride
-
 Homo sapiens
3-[(cyclopropylamino)methyl]-2-(3-methoxypropyl)-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide hydrochloride
-
 Homo sapiens
3-[1,3-dioxolan-2-yl]-N-(2-methoxyethyl)-2-thiophenesulfonamide
-
 Homo sapiens
3-[1,3-dioxolan-2-yl]-N-(3,4-dimethoxyphenyl)-2-thiophenesulfonamide
-
 Homo sapiens
3-[[bis(2-methoxyethyl)amino]methyl]-2-propyl-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide hydrochloride
-
 Homo sapiens
3-[[N-(2-methoxyethyl)-N-(2-propenyl)amino]methyl]-2-methyl-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide hydrochloride
-
 Homo sapiens
3-[[N-(2-methoxyethyl)-N-(3-methoxypropyl)amino]methyl]-2-methyl-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide hydrochloride
-
 Homo sapiens
3-[[N-(2-methoxyethyl)-N-methylamino]methyl]-2-methyl-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide
-
 Homo sapiens
4-bromo-5-(1,3-dioxalan-2-yl)-N-(1,1-dimethylethyl)-thiophene-2-sulfonamide
-
 Homo sapiens
acetazolamide
-
 Homo sapiens
brinzolamide
-
 Homo sapiens
dorzolamide
-
 Homo sapiens
ethyl 2-methyl-2H-thieno[2,3-e]-1,2-thiazine-3-carboxylate 1,1-dioxide
-
 Homo sapiens
ethyl 2-methyl-2H-thieno[3,2-e]-1,2-thiazine-3-carboxylate 1,1-dioxide
-
 Homo sapiens
ethyl 3,4-dihydro-4-hydroxy-2H-thieno[3,2-e]-1,2-thiazine-3-carboxylate 1,1-dioxide
-
 Homo sapiens
methazolamide
-
 Homo sapiens
methylbenzolamide
-
 Homo sapiens
N-(1,1-dimethylethyl)-2-(3-methoxyphenyl)-3-[(2-propylaminol)methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide
-
 Homo sapiens
N-(1,1-dimethylethyl)-2-(3-methoxyphenyl)-3-[(4-morpholinyl)methyl]-2H-thieno[3,2-e]-1,2-thiazine 1,1-dioxide
-
 Homo sapiens
N-(1,1-dimethylethyl)-2-[4-(4-morpholinyl)-2-butenyl]-2H-thieno[3,2-e-]-1,2-thiazine-6-sulfonamide 1,1-dioxide
-
 Homo sapiens
N-(cyclopropylmethyl)-3-(1,3-dioxolan-2-yl)thiophene-2-sulfonamide
-
 Homo sapiens
N-cyclohexyl-N-[(3-formyl-thien-2-yl)sulfonyl]-glycine methyl ester
-
 Homo sapiens
N-cyclopropylmethyl-3-(1,3-dioxolan-2-yl)-2-thiophenesulfonamide
-
 Homo sapiens
N-[(3-formyl-2-thienyl)sulfonyl]-glycine ethyl ester
-
 Homo sapiens
N-[(3-formyl-thien-2-yl)sulfonyl]-N-(2-methoxyethyl)-glycine ethyl ester
-
 Homo sapiens
N-[[2-(1,3-dioxalan-2-yl)-3-thienyl]sulfonyl]-N-methylglycine ethyl ester
-
 Homo sapiens
N-[[3-(1,3-dioxolan-2-yl)-2-thienyl]sulfonyl]-glycine ethyl ester
-
 Homo sapiens
N-[[3-(1,3-dioxolan-2-yl)thien-2-yl]sulfonyl]-N-(1-methylethyl)-glycine ethyl ester
-
 Homo sapiens
N-[[3-(1,3-dioxolan-2-yl)thien-2-yl]sulfonyl]-N-(2-propenyl)-glycine ethyl ester
-
 Homo sapiens
N-[[3-(1,3-dioxolan-2-yl)thien-2-yl]sulfonyl]-N-(3-methoxyethyl)-glycine ethyl ester
-
 Homo sapiens
N-[[3-(1,3-dioxolan-2-yl)thien-2-yl]sulfonyl]-N-ethylglycine ethyl ester
-
 Homo sapiens
N-[[3-(1,3-dioxolan-2-yl)thien-2-yl]sulfonyl]-N-methylcyclopropyl-glycine ethyl ester
-
 Homo sapiens
N-[[3-(1,3-dioxolan-2-yl)thien-2-yl]sulfonyl]-N-methylglycine ethyl ester
-
 Homo sapiens
N-[[3-(1,3-dioxolan-2-yl)thien-2-yl]sulfonyl]-N-propylglycine ethyl ester
-
 Homo sapiens
N-[[3-(1,3-dioxolan-2-yl)thien-2-yl]sulfonyl]-N-[(3,4-dimethoxyphenyl)methyl]-glycine ethyl ester
-
 Homo sapiens
N-[[3-(1,3-dioxolan-2-yl)thien-2-yl]sulfonyl]-N-[(3-methoxyphenyl)methyl]-glycine ethyl ester
-
 Homo sapiens
N-[[3-(1,3-dioxolan-2-yl)thien-2-yl]sulfonyl]-N-[(4-methoxyphenyl)methyl]-glycine ethyl ester
-
 Homo sapiens
N-[[3-(1,3-dioxolan-2-yl)thien-2-yl]sulfonyl]-N-[4-(morpholin-4-yl)phenyl]-glycine methyl ester
-
 Homo sapiens
N-[[5-(aminosulfonyl)-2-formyl-thiophen-3-yl]sulfonyl]-N-methyl-glycine ethyl ester
-
 Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
H2CO3 Homo sapiens
-
 CO2 + H2O
-
 r

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
H2CO3
-
 Homo sapiens CO2 + H2O
-
 r

Synonyms

Synonyms Comment Organism
CA
-
 Homo sapiens
carbonic anhydrase
-
 Homo sapiens
HCA II
-
 Homo sapiens
HCA-II
-
 Homo sapiens