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Literature summary for 4.2.1.1 extracted from

  • Jude, K.M.; Wright, S.K.; Tu, C.; Silverman, D.N.; Viola, R.E.; Christianson, D.W.
    Crystal structure of F65/Y131C-methylimidazole carbonic anhydrase V reveals architectural features of an engineered proton shuttle (2002), Biochemistry, 41, 2485-2491.
    View publication on PubMed
Search for more literature for 4.2.1.1

Cloned(Commentary)

Cloned (Comment) Organism
overexpressed in Escherichia coli Mus musculus

Crystallization (Commentary)

Crystallization (Comment) Organism
crystallized by the vapor diffusion method, hanging drop, space group C2, unit cell parameters a : 99.3 A, b : 66.7 A, c : 92.6 A Mus musculus

Protein Variants

Protein Variants Comment Organism
F65A/Y131C covalently modified at cysteine residues with 4-chloromethylimidazole, exhibits an up to 3fold enhancement of catalytic activity over that of wild-type Mus musculus
Y64H/F65A CAV variant, double mutation, transforms CAVeffectively into an anlogue of CAII, the prototypical carbonic anhydrase isozyme Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+
-
 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
H2CO3 Mus musculus
-
 CO2 + H2O
-
 r

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
H2CO3
-
 Mus musculus CO2 + H2O
-
 r

Synonyms

Synonyms Comment Organism
carbonic anhydrase
-
 Mus musculus
carbonic anhydrase V
-
 Mus musculus
CAV
-
 Mus musculus