Literature summary for 4.1.99.3 extracted from

Miyazawa, Y.; Nishioka, H.; Yura, K.; Yamato, T.
Discrimination of class I CPD photolyase from blue light photoreceptors by single methionine residue (2008), Biophys. J., 94, 2194-2203.

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Protein Variants

Protein Variants	Comment	Organism
additional information	by evolutionary sequence analysis it is shown that Met353 of the CPD photolyase derived from Anacystis nidulans is perfectly conserved throughout the putative class I CPD photolyase	Synechococcus elongatus PCC 7942 = FACHB-805
additional information	Met-353 of the CPD photolyase has been perfectly conserved throughout the putative class I CPD photolyases and plays a pivotal role in the biological function of DNA photolyase	Synechococcus elongatus PCC 7942 = FACHB-805

Organism

Organism	UniProt	Comment	Textmining
Synechococcus elongatus PCC 7942 = FACHB-805	-	-	-

Reaction

Reaction	Comment	Organism	Reaction ID
cyclobutadipyrimidine (in DNA) = 2 pyrimidine residues (in DNA)	by molecular dynamics simulation and quantum mechanical calculations it is shown that indirect electron tunneling via the protein medium is as important as direct electron transfer from the donor (FADH-) to the acceptor (cyclobutane pyrimidine dimmer). At Met353 site busy electron tunneling traffic is observed.	Synechococcus elongatus PCC 7942 = FACHB-805	a

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
cyclobutadipyrimidine in DNA	DNA photolyase recognizes ultraviolet-damaged DNA and breaks improperly formed covalent bonds within the cyclobutane pyrimidine dimer by a light-activated electron transfer reaction between FAD and cyclobutane pyrimidine dimer	Synechococcus elongatus PCC 7942 = FACHB-805	pyrimidine residues in DNA	-	?

Synonyms

Synonyms	Comment	Organism
class I CPD photolyase	-	Synechococcus elongatus PCC 7942 = FACHB-805
class I cyclobutane pyrimidine dimer photolyase	-	Synechococcus elongatus PCC 7942 = FACHB-805
CPD photolyase	-	Synechococcus elongatus PCC 7942 = FACHB-805
DNA photolyase	-	Synechococcus elongatus PCC 7942 = FACHB-805

Cofactor

Cofactor	Comment	Organism	Structure
FAD	-	Synechococcus elongatus PCC 7942 = FACHB-805
FADH2	-	Synechococcus elongatus PCC 7942 = FACHB-805

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Release 2023.1 (January 2023)