Literature summary for 4.1.99.2 extracted from

Kiick, D.M.; Phillips, R.S.
Mechanistic deductions from kinetic isotope effects and pH studies of pyridoxal phosphate dependent carbon-carbon lyases: Erwinia herbicola and Citrobacter freundii tyrosine phenol-lyase (1988), Biochemistry, 27, 7333-7338.

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Organism

Organism	UniProt	Comment	Textmining
Citrobacter freundii	-	-	-
Pantoea agglomerans	-	-	-

Reaction

Reaction	Comment	Organism	Reaction ID
L-tyrosine + H2O = phenol + pyruvate + NH3	mechanism appears to require two bases, one of which abstracts the proton from the 2-position of the substrate to form a quinonoid intermediate and the second of which acting in concert with proton transfer from the first group to C-1 of the phenolic ring, abstracts the substrate hydroxyl group to facilitate cyclohexadienone formation and subsequent elimination of phenol	Pantoea agglomerans	a
L-tyrosine + H2O = phenol + pyruvate + NH3	mechanism appears to require two bases, one of which abstracts the proton from the 2-position of the substrate to form a quinonoid intermediate and the second of which acting in concert with proton transfer from the first group to C-1 of the phenolic ring, abstracts the substrate hydroxyl group to facilitate cyclohexadienone formation and subsequent elimination of phenol	Citrobacter freundii	a

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Tyr + H2O	L-Tyr	Pantoea agglomerans	phenol + pyruvate + NH3	-	?
Tyr + H2O	L-Tyr	Citrobacter freundii	phenol + pyruvate + NH3	-	?

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Release 2023.1 (January 2023)