Crystallization (Comment) | Organism |
---|---|
to study how the enzyme recognizes the T(6-4)C and T(Dew)C lesion analogues in the active site, DNA duplexes are crystallized together with the (6-4) photolyase | Drosophila melanogaster |
Protein Variants | Comment | Organism |
---|---|---|
H365N | mutant shows no repair activity | Drosophila melanogaster |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Drosophila melanogaster | Q8SXK5 | - |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
(6-4) photoproduct (in DNA) = 2 pyrimidine residues (in DNA) | repair of Dewar valence isomers by (6-4) photolyases involves the rearrangement of the Dewar lesions into the corresponding (6-4) lesions. This reaction requires electron injection. (6-4) photolyases have two catalytic functions: Splitting (6-4) lesions and catalyzing the formal 4pi sigmatropic rearrangement of Dewar isomers to (6-4) lesions | Drosophila melanogaster |
Synonyms | Comment | Organism |
---|---|---|
(6-4) photolyase | - |
Drosophila melanogaster |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Drosophila melanogaster |