Literature summary for 4.1.99.13 extracted from

Sadeghian, K.; Bocola, M.; Merz, T.; Schuetz, M.
Theoretical study on the repair mechanism of the (6-4) photolesion by the (6-4) photolyase (2010), J. Am. Chem. Soc., 132, 16285-16295.

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Organism

Organism	UniProt	Comment	Textmining
Drosophila melanogaster	-	-	-

Reaction

Reaction	Comment	Organism	Reaction ID
(6-4) photoproduct (in DNA) = 2 pyrimidine residues (in DNA)	using quantum mechanics/molecular mechanics studies, a repair mechanism is proposed, which involves two photoexcitations. The flavin chromophore, initially being in its reduced anionic form, is photoexcited and donates an electron to the (6-4) form of the photolesion. The photolesion is then protonated by the neighboring histidine residue and forms a radical intermediate. A second photoexcitation of the flavin promotes another electron transfer to the oxetane. Proton donation from the same histidine residue allows for the splitting of the four-membered ring, hence opening an efficient pathway to the final repaired form	Drosophila melanogaster	a

Synonyms

Synonyms	Comment	Organism
(6-4) photolyase	-	Drosophila melanogaster

Cofactor

Cofactor	Comment	Organism	Structure
FAD	-	Drosophila melanogaster

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Release 2023.1 (January 2023)