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Literature summary for 4.1.99.13 extracted from
- Structural biology of DNA photolyases and cryptochromes (2009), Curr. Opin. Struct. Biol., 19, 277-285.
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| two crystal structures of the (6-4) photolyase bound to lesion containing DNA before and after repair, repair does not involve oxetane formation before light-induced electron transfer. The histidine 369, supposed to activate the acylimine, is in a position that does not allow efficient proton donation and hence activation of this substructure | Drosophila melanogaster |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Arabidopsis thaliana | O48652 | - |
- |
| Drosophila melanogaster | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| T(6-4)T photoproduct (in DNA) | - |
Drosophila melanogaster | 2 thymidine residues (in DNA) | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| (6-4) photolyase | - |
Drosophila melanogaster |
| (6-4) photolyase | - |
Arabidopsis thaliana |
| (6-4)-Phr | - |
Drosophila melanogaster |
| (6-4)-Phr | - |
Arabidopsis thaliana |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| 8-hydroxy-5-deazariboflavin | - |
Drosophila melanogaster | |
| FAD | in the structure of (6-4) photolyase, there is a phosphate anion bound to Glu-243 and Trp-238, close to FAD | Arabidopsis thaliana | |
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