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Literature summary for 4.1.99.1 extracted from

  • Scherzer, R.; Gdalevsky, G.; Goldgur, Y.; Cohen-Luria, R.; Bittner, S.; Parola, A.
    New tryptophanase inhibitors: Towards prevention of bacterial biofilm formation (2009), J. Enzyme Inhib. Med. Chem., 24, 350-355.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
alpha-amino-9,10-dihydro-9,10-dioxo-2-anthracenepropanoic acid noncompetitive inhibition Escherichia coli
L-tryptophan ethylester competitive inhibition Escherichia coli
N-acetyl-L-tryptophan noncompetitive inhibition Escherichia coli
N-[3,6-dioxo-4-(phenylsulfanyl)cyclohexa-1,4-dien-1-yl]-L-tryptophanamide uncompetitive inhibition Escherichia coli
oxindolyl-L-alanine
-
Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-Trp + H2O
-
Escherichia coli indole + pyruvate + NH4+
-
r
S-(2-nitrophenyl)-L-cysteine + H2O
-
Escherichia coli 2-nitrobenzenethiolate + pyruvate + NH3
-
ir

Synonyms

Synonyms Comment Organism
TNase
-
Escherichia coli
tryptophan-indole lyase
-
Escherichia coli

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
Escherichia coli

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.005
-
oxindolyl-L-alanine in 50 mM potassium phosphate buffer (pH 7.8), at 25°C Escherichia coli
48
-
N-acetyl-L-tryptophan in 50 mM potassium phosphate buffer (pH 7.8), at 25°C Escherichia coli
52
-
L-tryptophan ethylester in 50 mM potassium phosphate buffer (pH 7.8), at 25°C Escherichia coli
101
-
N-[3,6-dioxo-4-(phenylsulfanyl)cyclohexa-1,4-dien-1-yl]-L-tryptophanamide in 50 mM potassium phosphate buffer (pH 7.8), at 25°C Escherichia coli
174
-
alpha-amino-9,10-dihydro-9,10-dioxo-2-anthracenepropanoic acid in 50 mM potassium phosphate buffer (pH 7.8), at 25°C Escherichia coli