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Literature summary for 4.1.3.42 extracted from

  • Patil, R.V.; Dekker, E.E.
    Cloning, nucleotide sequence, overexpression, and inactivation of the Escherichia coli 2-keto-4-hydroxyglutarate aldolase gene (1992), J. Bacteriol., 174, 102-107.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
-
Escherichia coli
overexpressed in pKK223.3 expression vector Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
additional information gene inactivation Escherichia coli

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.6
-
(4S)-4-hydroxy-2-oxoglutarate pH 8.4, 25°C Escherichia coli

Metals/Ions

Metals/Ions Comment Organism Structure
additional information no requirement Escherichia coli

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
22000
-
3 * 22284, calculated, 3 * 22000, SDS-PAGE Escherichia coli
22284
-
3 * 22284, calculated, 3 * 22000, SDS-PAGE Escherichia coli
62500
-
gel filtration Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Escherichia coli
-
overexpressed after cloning into pKK223.3 expression vector
-
Escherichia coli P0A955
-
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
80fold increase in specific activity after overexpression in pKK223.3 Escherichia coli
45
-
pH 8.4, 25°C Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(4S)-4-hydroxy-2-oxoglutarate
-
Escherichia coli pyruvate + glyoxylate
-
?

Subunits

Subunits Comment Organism
trimer 3 * 22284, calculated, 3 * 22000, SDS-PAGE Escherichia coli

Synonyms

Synonyms Comment Organism
2-keto-4-hydroxybutyrate aldolase ambiguous Escherichia coli
2-keto-4-hydroxyglutarate aldolase ambiguous Escherichia coli
2-keto-4-hydroxyglutaric aldolase ambiguous Escherichia coli
2-oxo-4-hydroxyglutarate aldolase ambiguous Escherichia coli
2-oxo-4-hydroxyglutaric aldolase ambiguous Escherichia coli
4-hydroxy-2-ketoglutarate aldolase ambiguous Escherichia coli
4-hydroxy-2-ketoglutaric aldolase ambiguous Escherichia coli
4-hydroxy-2-oxoglutarate glyoxylate-lyase ambiguous Escherichia coli
eda
-
Escherichia coli
HGA
-
Escherichia coli
hydroxyketoglutarate aldolase ambiguous Escherichia coli
Hydroxyketoglutaric aldolase ambiguous Escherichia coli
KHG/KDPG aldolase
-
Escherichia coli

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.4
-
-
Escherichia coli