Cloned (Comment) | Organism |
---|---|
gene npl, realtime RT-PCR enzyme expression analysis | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Mus musculus B6/129S5-NplGt(IRESBetageo)332Lex/Mmucd | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
uterus | progesterone-mediated dynamic expression of the enzyme in the periimplantation uterus, Npl expression increases 56fold from gestation day 0.5 to day 2.5. In ovariectomized mouse uterus | Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
N-acetylneuraminate pyruvate lyase | - |
Mus musculus |
NPL | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | gene npl is downregulated by 17beta-estradiol | down |
Mus musculus | gene npl is significantly upregulated by progesterone. Progesterone receptor antagonist RU486 blocks the upregulation of Npl in both preimplantation uterus and progesterone-treated ovariectomized uterus | up |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme regulates the cellular concentrations of sialic acid and preventing the recycling of sialic acid for further sialiation with glycoconjuates in the Golgi compartment. The enzyme plays a dispensable role in uterine function and embryo development | Mus musculus |