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Literature summary for 4.1.2.48 extracted from
- Enhanced synthesis of L-threo-3,4-dihydroxyphenylserine by high-density whole-cell biocatalyst of recombinant L-threonine aldolase from Streptomyces avelmitilis (2009), Biotechnol. Lett., 31, 443-448.
Application
| Application | Comment | Organism |
|---|---|---|
| biotechnology | a continuous bioconversion system for L-threo-3,4-dihydroxyphenylserine production is developed that uses whole-cell biocatalyst of recombinant Escherichia coli expressing L-TA genes cloned from Streptomyces avelmitilis MA-4680. Maximum conversion rates are observed at 2 M glycine, 145 mM 3,4-dihydroxybenzaldehyde, 0.75% Triton-X, 5 g Escherichia coli cells/l, pH 6.5 and 10°C. In the optimized condition, overall productivity is 8 g/l | Streptomyces avermitilis |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| recombinantly expressed in Escherichia coli | Streptomyces avermitilis |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Streptomyces avermitilis | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| glycine + 3,4-dihydroxybenzaldehyde | - |
Streptomyces avermitilis | L-threo-3,4-dihydroxyphenylserine | - |
r |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| L-TA | - |
Streptomyces avermitilis |
| threonine aldolase | - |
Streptomyces avermitilis |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 10 | - |
- |
Streptomyces avermitilis |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.5 | - |
- |
Streptomyces avermitilis |
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