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Literature summary for 4.1.2.4 extracted from

  • Wong, C.H.; Garcia-Junceda, E.; Chen, L.; Blanco, O.; Gijsen, H.J.M.; Steensma, D.H.
    Recombinant 2-deoxyribose-5-phosphate aldolase in organic synthesis: use of sequential two-substrate and three-substrate aldol reactions (1995), J. Am. Chem. Soc., 117, 3333-3339.
No PubMed abstract available

Application

Application Comment Organism
synthesis synthesis of a variety of sugar analogs, including 2-deoxy-L-fucose and analogs, thiosugars and glycolipid precursors. The sequential aldol reaction is utilized in the synthesis of a variety of 2,4-dideoxyhexoses and 2,4,6-trideoxyhexoses Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
strain DH5alpha
-
Escherichia coli DH5-alpha
-
strain DH5alpha
-

Purification (Commentary)

Purification (Comment) Organism
large scale Escherichia coli

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(R)-3-Bromo-2-hydroxypropanal + acetaldehyde
-
Escherichia coli 5-Bromo-2-deoxyribose
-
?
(R)-3-Bromo-2-hydroxypropanal + acetaldehyde
-
Escherichia coli DH5-alpha 5-Bromo-2-deoxyribose
-
?
2-deoxy-D-ribose 5-phosphate
-
Escherichia coli D-glyceraldehyde 3-phosphate + acetaldehyde
-
?
2-deoxy-D-ribose 5-phosphate
-
Escherichia coli DH5-alpha D-glyceraldehyde 3-phosphate + acetaldehyde
-
?
2-hydroxy-3-butenal + acetaldehyde
-
Escherichia coli 2,5,6-trideoxy-D-erythro-5-hexenose
-
?
2-hydroxy-3-butenal + acetaldehyde
-
Escherichia coli DH5-alpha 2,5,6-trideoxy-D-erythro-5-hexenose
-
?
3-Azido-3-deoxy-erythrose + acetaldehyde
-
Escherichia coli 5-Azidohexofuranose
-
?
3-Chloro-2-hydroxypropanal + propionaldehyde
-
Escherichia coli 5-Chloro-2-methylribose
-
?
3-Chloro-2-hydroxypropanal + propionaldehyde
-
Escherichia coli DH5-alpha 5-Chloro-2-methylribose
-
?
3-Thioglyceraldehyde + acetaldehyde
-
Escherichia coli 2-Deoxy-5-thio-D-erythro-pentose
-
?
additional information sequential two-substrate and three-substrate aldol reactions Escherichia coli ?
-
?
additional information sequential two-substrate and three-substrate aldol reactions Escherichia coli DH5-alpha ?
-
?