Literature summary for 4.1.2.38 extracted from

Mueller, C.R.; Perez-Sanchez, M.; Dominguez de Maria, P.
Benzaldehyde lyase-catalyzed diastereoselective C-C bond formation by simultaneous carboligation and kinetic resolution (2013), Org. Biomol. Chem., 11, 2000-2004.

Search for more literature for 4.1.2.38

Organism

Organism	UniProt	Comment	Textmining
Pseudomonas fluorescens	P51853	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
benzaldehyde + 2-methylbutanal	-	Pseudomonas fluorescens	(2R,3S)-2-hydroxy-3-methyl-1-phenylpentan-1-one + 1-hydroxy-3-methyl-1-phenylpentan-2-one	63% (2R,3S)-2-hydroxy-3-methyl-1-phenylpentan-1-one, 85% syn product, plus 37% 1-hydroxy-3-methyl-1-phenylpentan-2-one, 40% syn product	?
benzaldehyde + 2-methylpentanal	-	Pseudomonas fluorescens	(2R,3S)-2-hydroxy-3-methyl-1-phenylhexan-1-one + 1-hydroxy-3-methyl-1-phenylhexan-2-one	50% (2R,3S)-2-hydroxy-3-methyl-1-phenylhexan-1-one, more than 99% syn poduct, plus 50% 1-hydroxy-3-methyl-1-phenylhexan-2-one	?
benzaldehyde + 2-methylpropanal	-	Pseudomonas fluorescens	(2R)-2-hydroxy-3-methyl-1-phenylbutan-1-one + 1-hydroxy-3-methyl-1-phenylbutan-2-one	50% (2R)-2-hydroxy-3-methyl-1-phenylbutan-1-one, more than 99% enantiomeric excess, plus 50% 1-hydroxy-3-methyl-1-phenylbutan-2-one, 93% enantiomeric excess	?
additional information	enzyme catalyzes the diastereoselective carboligation of aldehydes when benzaldehyde acts as the donor, and (+/-)-2-methyl-alkyl-aldehydes are used as acceptor substrates. When benzaldehyde is taken as an acceptor aldehyde, the diastereoselectivities obtained are poor in all cases tested	Pseudomonas fluorescens	?	-	?

Synonyms

Synonyms	Comment	Organism
BAL	-	Pseudomonas fluorescens
BznB	-	Pseudomonas fluorescens

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Release 2023.1 (January 2023)