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Literature summary for 4.1.2.27 extracted from

  • Serra, M.; Saba, J.
    Sphingosine 1-phosphate lyase, a key regulator of sphingosine 1-phosphate signaling and function (2010), Adv. Enzyme Regul., 50, 349-362.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
1-desoxysphinganine 1-phosphonate competitive inhibitor Homo sapiens
1-desoxysphinganine 1-phosphonate competitive inhibitor Mus musculus
1-desoxysphinganine 1-phosphonate competitive inhibitor Rattus norvegicus
2-acetyl-4-(1R,2S,3R,4-tetrahydroxybutyl)-imidazole
-
Homo sapiens
2-acetyl-4-(1R,2S,3R,4-tetrahydroxybutyl)-imidazole
-
Mus musculus
2-acetyl-4-(1R,2S,3R,4-tetrahydroxybutyl)-imidazole
-
Rattus norvegicus
2-vinyl dihydrosphingosine
-
Homo sapiens
2-vinyl dihydrosphingosine
-
Mus musculus
2-vinyl dihydrosphingosine
-
Rattus norvegicus
4'-deoxypyridoxine a pyridoxal 5'-phosphate analog Homo sapiens
4'-deoxypyridoxine a pyridoxal 5'-phosphate analog Mus musculus
4'-deoxypyridoxine a pyridoxal 5’-phosphate analog Rattus norvegicus
N-[(1R,2S)-2-hydroxy-1-hydroxymethyl-2-(2-tridecyl-1-cyclopentenyl)ethyl]octanamide
-
Homo sapiens
N-[(1R,2S)-2-hydroxy-1-hydroxymethyl-2-(2-tridecyl-1-cyclopentenyl)ethyl]octanamide
-
Mus musculus
N-[(1R,2S)-2-hydroxy-1-hydroxymethyl-2-(2-tridecyl-1-cyclopentenyl)ethyl]octanamide
-
Rattus norvegicus
[2-amino-2[2-(4-octylphenyl)ethyl]-3-hydroxypropyl]dihydrogen phosphate
-
Homo sapiens
[2-amino-2[2-(4-octylphenyl)ethyl]-3-hydroxypropyl]dihydrogen phosphate
-
Mus musculus
[2-amino-2[2-(4-octylphenyl)ethyl]-3-hydroxypropyl]dihydrogen phosphate
-
Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Rattus norvegicus
-
-
mitochondrial membrane
-
Homo sapiens 31966
-
mitochondrial membrane
-
Mus musculus 31966
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus Q8R0X7
-
-
Rattus norvegicus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein
-
Homo sapiens
glycoprotein
-
Mus musculus
nitrosylation nitrosylation on tyrosine residues Y356 and Y366 Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
brain low expression Mus musculus
-
colon high expression Mus musculus
-
harderian gland high expression Mus musculus
-
heart low expression Mus musculus
-
HEK-293 cell
-
Homo sapiens
-
kidney moderate expression Mus musculus
-
liver
-
Rattus norvegicus
-
liver moderate expression Mus musculus
-
lung moderate expression Mus musculus
-
olfactory epithelium the enzyme is highly enriched in olfactory mucosal epithelium Mus musculus
-
skeletal muscle low expression Mus musculus
-
small intestine high expression Mus musculus
-
spleen high expression Mus musculus
-
stomach moderate expression Mus musculus
-
testis moderate expression Mus musculus
-
thymus high expression Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7-nitrobenz-2-oxa-1,3-diazole-sphingosine 1-phosphate
-
Homo sapiens phosphoethanolamine + 7-nitrobenz-2-oxa-1,3-diazole-hexadec-2-enal
-
?
7-nitrobenz-2-oxa-1,3-diazole-sphingosine 1-phosphate
-
Rattus norvegicus phosphoethanolamine + 7-nitrobenz-2-oxa-1,3-diazole-hexadec-2-enal
-
?
7-nitrobenz-2-oxa-1,3-diazole-sphingosine 1-phosphate
-
Mus musculus phosphoethanolamine + 7-nitrobenz-2-oxa-1,3-diazole-hexadec-2-enal
-
?
boron dipyrromethene difluoride-sphingosine 1-phosphate
-
Homo sapiens phosphoethanolamine + boron dipyrromethene difluoride-hexadec-2-enal
-
?
boron dipyrromethene difluoride-sphingosine 1-phosphate
-
Rattus norvegicus phosphoethanolamine + boron dipyrromethene difluoride-hexadec-2-enal
-
?
boron dipyrromethene difluoride-sphingosine 1-phosphate
-
Mus musculus phosphoethanolamine + boron dipyrromethene difluoride-hexadec-2-enal
-
?
D-(+)-erythro-sphingosine 1-phosphate
-
Homo sapiens phosphoethanolamine + (2E)-hexadecenal
-
ir
D-(+)-erythro-sphingosine 1-phosphate
-
Rattus norvegicus phosphoethanolamine + (2E)-hexadecenal
-
ir
D-(+)-erythro-sphingosine 1-phosphate
-
Mus musculus phosphoethanolamine + (2E)-hexadecenal
-
ir
umbelliferone-labled sphinganine 1-phosphate
-
Homo sapiens phosphoethanolamine + 3-[(2-oxo-2H-chromen-7-yl)oxy]propanal
-
?
umbelliferone-labled sphinganine 1-phosphate
-
Rattus norvegicus phosphoethanolamine + 3-[(2-oxo-2H-chromen-7-yl)oxy]propanal
-
?
umbelliferone-labled sphinganine 1-phosphate
-
Mus musculus phosphoethanolamine + 3-[(2-oxo-2H-chromen-7-yl)oxy]propanal
-
?

Subunits

Subunits Comment Organism
tetramer or hexamer
-
Homo sapiens
tetramer or hexamer
-
Rattus norvegicus
tetramer or hexamer
-
Mus musculus

Synonyms

Synonyms Comment Organism
dihydrosphingosine phosphate lyase
-
Homo sapiens
dihydrosphingosine phosphate lyase
-
Rattus norvegicus
dihydrosphingosine phosphate lyase
-
Mus musculus
Dpl1
-
Homo sapiens
Dpl1
-
Rattus norvegicus
Dpl1
-
Mus musculus
S1P lyase
-
Homo sapiens
S1P lyase
-
Rattus norvegicus
S1P lyase
-
Mus musculus
sphingosine 1-phosphate lyase
-
Homo sapiens
sphingosine 1-phosphate lyase
-
Rattus norvegicus
sphingosine 1-phosphate lyase
-
Mus musculus
SPL
-
Homo sapiens
SPL
-
Rattus norvegicus
SPL
-
Mus musculus

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate dependent on Homo sapiens
pyridoxal 5'-phosphate dependent on Rattus norvegicus
pyridoxal 5'-phosphate dependent on Mus musculus

General Information

General Information Comment Organism
physiological function SPL is the final enzyme in the sphingolipid degradative pathway and an important regulator of sphingosine 1-phosphate as well as the levels of other sphingolipid intermediates which influence various aspects of cell growth, proliferation and death. SPL is necessary for maintaining lipid homeostasis and appropriate cell fate responses. SPL serves as a therapeutic target for immune modulation Homo sapiens
physiological function SPL is the final enzyme in the sphingolipid degradative pathway and an important regulator of sphingosine 1-phosphate as well as the levels of other sphingolipid intermediates which influence various aspects of cell growth, proliferation and death. SPL is necessary for maintaining lipid homeostasis and appropriate cell fate responses. SPL serves as a therapeutic target for immune modulation Rattus norvegicus
physiological function SPL is the final enzyme in the sphingolipid degradative pathway and an important regulator of sphingosine 1-phosphate as well as the levels of other sphingolipid intermediates which influence various aspects of cell growth, proliferation and death. SPL is necessary for maintaining lipid homeostasis and appropriate cell fate responses. SPL serves as a therapeutic target for immune modulation Mus musculus