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Literature summary for 4.1.2.27 extracted from

  • Vogel, P.; Donoviel, M.S.; Read, R.; Hansen, G.M.; Hazlewood, J.; Anderson, S.J.; Sun, W.; Swaffield, J.; Oravecz, T.
    Incomplete inhibition of sphingosine 1-phosphate lyase modulates immune system function yet prevents early lethality and non-lymphoid lesions (2009), PLoS ONE, 4, e4112.
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine all S1PL-deficient genetic models used display lymphopenia, with sequestration of mature T-cells in the thymus and lymph nodes. In addition to the lymphoid phenotypes, S1PL KO mice also develop myeloid cell hyperplasia and significant lesions in the lung, heart, urinary tract, and bone, and have a markedly reduced life span. Complete absence of S1PL affects both maturation/development and egress of mature T cells from the thymus, whereas low level S1PL activity affects T-cell egress more than differentiation Mus musculus
medicine humanized knock-in mice harboring one allele such as S1PLH/- or two alleles such as S1PLH/H of human S1PL express less than 10 and 20% of normal S1PL activity, respectively. This partial restoration of S1PL activity is sufficient to fully protect both humanized mouse lines from the lethal non-lymphoid lesions that develop in S1PL-/- mice, but fails to restore normal T-cell development and trafficking. The complete absence of S1PL affects both maturation/development and egress of mature T-cells from the thymus, whereas low level S1PL activity affects T-cell egress more than differentiation Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression in Mus musculus Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Mus musculus Q8R0X7
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-

General Information

General Information Comment Organism
physiological function all S1PL-deficient genetic models used display lymphopenia, with sequestration of mature T-cells in the thymus and lymph nodes. In addition to the lymphoid phenotypes, S1PL KO mice also develop myeloid cell hyperplasia and significant lesions in the lung, heart, urinary tract, and bone, and have a markedly reduced life span. Complete absence of S1PL affects both maturation/development and egress of mature T cells from the thymus, whereas low level S1PL activity affects T-cell egress more than differentiation Homo sapiens
physiological function all S1PL-deficient genetic models used display lymphopenia, with sequestration of mature T-cells in the thymus and lymph nodes. In addition to the lymphoid phenotypes, S1PL KO mice also develop myeloid cell hyperplasia and significant lesions in the lung, heart, urinary tract, and bone, and have a markedly reduced life span. Complete absence of S1PL affects both maturation/development and egress of mature T cells from the thymus, whereas low level S1PL activity affects T-cell egress more than differentiation Mus musculus