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Literature summary for 4.1.2.27 extracted from
- Sphingosine-1-phosphate lyase in immunity and cancer: silencing the siren (2007), Trends Mol. Med., 13, 210-217.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2-acetyl-4-tetrahydroxybutylimidazole | - |
Caenorhabditis elegans |  |
| 2-acetyl-4-tetrahydroxybutylimidazole | - |
Drosophila melanogaster | |
| 2-acetyl-4-tetrahydroxybutylimidazole | - |
Homo sapiens | |
| 2-acetyl-4-tetrahydroxybutylimidazole | - |
Mus musculus | |
| 2-acetyl-4-tetrahydroxybutylimidazole | - |
Rattus norvegicus | |
| bisulfite | - |
Caenorhabditis elegans | |
| bisulfite | - |
Drosophila melanogaster | |
| bisulfite | - |
Homo sapiens | |
| bisulfite | - |
Mus musculus | |
| bisulfite | - |
Rattus norvegicus | |
| cyanide | - |
Caenorhabditis elegans | |
| cyanide | - |
Drosophila melanogaster | |
| cyanide | - |
Homo sapiens | |
| cyanide | - |
Mus musculus | |
| cyanide | - |
Rattus norvegicus | |
| cysteine | - |
Caenorhabditis elegans | |
| cysteine | - |
Drosophila melanogaster | |
| cysteine | - |
Homo sapiens | |
| cysteine | - |
Mus musculus | |
| cysteine | - |
Rattus norvegicus | |
| deoxypyridoxine | competitive inhibitor | Caenorhabditis elegans | |
| deoxypyridoxine | competitive inhibitor | Drosophila melanogaster | |
| deoxypyridoxine | competitive inhibitor | Homo sapiens | |
| deoxypyridoxine | competitive inhibitor | Mus musculus | |
| deoxypyridoxine | competitive inhibitor | Rattus norvegicus | |
| FTY720 | - |
Caenorhabditis elegans | |
| FTY720 | - |
Drosophila melanogaster | |
| FTY720 | - |
Homo sapiens | |
| FTY720 | - |
Mus musculus | |
| FTY720 | - |
Rattus norvegicus | |
| Semicarbazide | - |
Caenorhabditis elegans | |
| Semicarbazide | - |
Drosophila melanogaster | |
| Semicarbazide | - |
Homo sapiens | |
| Semicarbazide | - |
Mus musculus | |
| Semicarbazide | - |
Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| endoplasmic reticulum | - |
Drosophila melanogaster | 5783 | - |
| endoplasmic reticulum | - |
Mus musculus | 5783 | - |
| endoplasmic reticulum | - |
Homo sapiens | 5783 | - |
| endoplasmic reticulum | - |
Rattus norvegicus | 5783 | - |
| endoplasmic reticulum | - |
Caenorhabditis elegans | 5783 | - |
| microsome | - |
Drosophila melanogaster | - |
- |
| microsome | - |
Mus musculus | - |
- |
| microsome | - |
Homo sapiens | - |
- |
| microsome | - |
Rattus norvegicus | - |
- |
| microsome | - |
Caenorhabditis elegans | - |
- |
| mitochondrion | - |
Drosophila melanogaster | 5739 | - |
| mitochondrion | - |
Mus musculus | 5739 | - |
| mitochondrion | - |
Homo sapiens | 5739 | - |
| mitochondrion | - |
Rattus norvegicus | 5739 | - |
| mitochondrion | - |
Caenorhabditis elegans | 5739 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 63500 | - |
SDS-PAGE | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Caenorhabditis elegans | - |
- |
- |
| Dictyostelium discoideum | - |
- |
- |
| Drosophila melanogaster | - |
- |
- |
| Homo sapiens | - |
- |
- |
| Leishmania major | - |
- |
- |
| Mus musculus | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Mus musculus | - |
| brain | - |
Rattus norvegicus | - |
| colon | - |
Mus musculus | - |
| colon | - |
Rattus norvegicus | - |
| gut | - |
Drosophila melanogaster | - |
| gut | - |
Caenorhabditis elegans | - |
| heart | - |
Mus musculus | - |
| heart | - |
Rattus norvegicus | - |
| liver | - |
Mus musculus | - |
| liver | - |
Rattus norvegicus | - |
| lymphocyte | - |
Homo sapiens | - |
| small intestine | - |
Mus musculus | - |
| small intestine | - |
Rattus norvegicus | - |
| thymus | - |
Mus musculus | - |
| thymus | - |
Homo sapiens | - |
| thymus | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| sphingosine 1-phosphate | - |
Drosophila melanogaster | phosphoethanolamine + palmitaldehyde | - |
ir | |
| sphingosine 1-phosphate | - |
Mus musculus | phosphoethanolamine + palmitaldehyde | - |
ir | |
| sphingosine 1-phosphate | - |
Rattus norvegicus | phosphoethanolamine + palmitaldehyde | - |
ir | |
| sphingosine 1-phosphate | - |
Dictyostelium discoideum | phosphoethanolamine + palmitaldehyde | - |
ir | |
| sphingosine 1-phosphate | - |
Caenorhabditis elegans | phosphoethanolamine + palmitaldehyde | - |
ir | |
| sphingosine 1-phosphate | - |
Leishmania major | phosphoethanolamine + palmitaldehyde | - |
ir | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| sphingosine-1-phosphate lyase | - |
Drosophila melanogaster |
| sphingosine-1-phosphate lyase | - |
Mus musculus |
| sphingosine-1-phosphate lyase | - |
Homo sapiens |
| sphingosine-1-phosphate lyase | - |
Rattus norvegicus |
| sphingosine-1-phosphate lyase | - |
Dictyostelium discoideum |
| sphingosine-1-phosphate lyase | - |
Caenorhabditis elegans |
| sphingosine-1-phosphate lyase | - |
Leishmania major |
| SPL | - |
Drosophila melanogaster |
| SPL | - |
Mus musculus |
| SPL | - |
Homo sapiens |
| SPL | - |
Rattus norvegicus |
| SPL | - |
Dictyostelium discoideum |
| SPL | - |
Caenorhabditis elegans |
| SPL | - |
Leishmania major |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| pyridoxal 5'-phosphate | - |
Drosophila melanogaster | |
| pyridoxal 5'-phosphate | - |
Mus musculus | |
| pyridoxal 5'-phosphate | - |
Homo sapiens | |
| pyridoxal 5'-phosphate | - |
Rattus norvegicus | |
| pyridoxal 5'-phosphate | - |
Dictyostelium discoideum | |
| pyridoxal 5'-phosphate | - |
Caenorhabditis elegans | |
| pyridoxal 5'-phosphate | - |
Leishmania major | |
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Release 2023.1 (January 2023)
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