Any feedback?
Literature summary for 4.1.2.27 extracted from
- Distribution and properties of dihydrosphingosine-1-phosphate aldolase (Sphinganine-1-phosphate alkanal-lyase) (1969), Hoppe-Seyler's Z. Physiol. Chem., 350, 1233-1241.
General Stability
| General Stability | Organism |
|---|---|
| stable towards Triton X-100 and no significant inhibition of the enzyme is observed up to a concentration of 15 mg/ml | Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Deoxypyridoxine phosphate | 50% inhibition at a concentration of 1.5 mM | Rattus norvegicus |  |
| iodoacetamide | complete inhibition | Rattus norvegicus | |
| N-ethylmaleimide | complete inhibition | Rattus norvegicus | |
| p-chloromercuribenzoate | complete inhibition | Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| endoplasmic reticulum | membrane-bound enzyme | Rattus norvegicus | 5783 | - |
| endoplasmic reticulum | membrane-bound enzyme | Sus scrofa | 5783 | - |
| endoplasmic reticulum | membrane-bound enzyme | Bos taurus | 5783 | - |
| endoplasmic reticulum | membrane-bound enzyme | Wickerhamomyces ciferrii | 5783 | - |
| microsome | - |
Sus scrofa | - |
- |
| microsome | - |
Bos taurus | - |
- |
| microsome | highest enzyme activity | Rattus norvegicus | - |
- |
| microsome | highest enzyme activity | Wickerhamomyces ciferrii | - |
- |
| mitochondrial inner membrane | inner mitochondrial membrane possesses the highest activity | Rattus norvegicus | 5743 | - |
| mitochondrial inner membrane | membrane-bound | Rattus norvegicus | 5743 | - |
| mitochondrial inner membrane | membrane-bound | Sus scrofa | 5743 | - |
| mitochondrial inner membrane | membrane-bound | Bos taurus | 5743 | - |
| mitochondrial inner membrane | membrane-bound | Wickerhamomyces ciferrii | 5743 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| F- | NaF required to inhibit phosphatases which rapidly hydrolyse the substrate sphinganine 1-phosphate and the coenzyme pyridoxal phosphate | Rattus norvegicus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Sus scrofa | - |
? | - |
? | |
| additional information | Bos taurus | - |
? | - |
? | |
| additional information | Wickerhamomyces ciferrii | - |
? | - |
? | |
| additional information | Rattus norvegicus | metabolic relationship between substrates and products of biosynthesis and degradation of sphingosine bases | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
| Sus scrofa | - |
- |
- |
| Wickerhamomyces ciferrii | - |
yeast | - |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| Sphinganine 1-phosphate = phosphoethanolamine + palmitaldehyde | irreversible reaction | Rattus norvegicus | |
| Sphinganine 1-phosphate = phosphoethanolamine + palmitaldehyde | pyridoxal phosphate dependent catalysis | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Rattus norvegicus | - |
| heart | - |
Rattus norvegicus | - |
| kidney | - |
Rattus norvegicus | - |
| kidney | - |
Sus scrofa | - |
| liver | - |
Rattus norvegicus | - |
| liver | - |
Sus scrofa | - |
| liver | - |
Bos taurus | - |
| lung | - |
Rattus norvegicus | - |
| muscle | - |
Rattus norvegicus | - |
| spleen | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4D-Hydroxysphinganine 1-phosphate | - |
Rattus norvegicus | Phosphoethanolamine + 2-hydroxyhexadecanal | - |
? | |
| 4D-Hydroxysphinganine 1-phosphate | - |
Wickerhamomyces ciferrii | Phosphoethanolamine + 2-hydroxyhexadecanal | - |
? | |
| additional information | - |
Rattus norvegicus | ? | - |
? | |
| additional information | - |
Sus scrofa | ? | - |
? | |
| additional information | - |
Bos taurus | ? | - |
? | |
| additional information | - |
Wickerhamomyces ciferrii | ? | - |
? | |
| additional information | metabolic relationship between substrates and products of biosynthesis and degradation of sphingosine bases | Rattus norvegicus | ? | - |
? | |
| sphinganine 1-phosphate | dihydrosphingosine-1-phosphate | Rattus norvegicus | phosphoethanolamine + palmitaldehyde | - |
? | |
| sphinganine 1-phosphate | dihydrosphingosine-1-phosphate | Sus scrofa | phosphoethanolamine + palmitaldehyde | - |
? | |
| sphinganine 1-phosphate | dihydrosphingosine-1-phosphate | Bos taurus | phosphoethanolamine + palmitaldehyde | - |
? | |
| sphinganine 1-phosphate | dihydrosphingosine-1-phosphate | Wickerhamomyces ciferrii | phosphoethanolamine + palmitaldehyde | - |
? | |
| sphinganine 1-phosphate | erythro-DL-dihydrosphingosine 1-phosphate | Rattus norvegicus | phosphoethanolamine + palmitaldehyde | - |
? | |
| sphinganine 1-phosphate | threo-dihydrosphingosine 1-phosphate | Rattus norvegicus | phosphoethanolamine + palmitaldehyde | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | 7.6 | - |
Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| pyridoxal 5'-phosphate | - |
Rattus norvegicus | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 1.5 | - |
Deoxypyridoxine phosphate | - |
Rattus norvegicus | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
