Activating Compound | Comment | Organism | Structure |
---|---|---|---|
AMP | acts as a very potent activator, 20 microM AMP is capable of increasing Xfp2 activity by 24.8%, while 50 microM prevent inhibition caused by 0.6 mM ATP. AMP and phosphoenolpyruvate/oxaloacetic acid operate independently, with AMP activating Xfp2 and phosphoenolpyruvate/oxaloacetic acid inhibiting the activated enzyme | Cryptococcus neoformans |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ATP | phosphoenolpyruvate and oxaloacetic acid share the same or have overlapping allosteric binding sites, while ATP binds at a separate site | Cryptococcus neoformans | |
oxaloacetic acid | phosphoenolpyruvate and oxaloacetic acid share the same or have overlapping allosteric binding sites, while ATP binds at a separate site. AMP and phosphoenolpyruvate/oxaloacetic acid operate independently, with AMP activating Xfp2 and phosphoenolpyruvate/oxaloacetic acid inhibiting the activated enzyme | Cryptococcus neoformans | |
phosphoenolpyruvate | phosphoenolpyruvate and oxaloacetic acid share the same or have overlapping allosteric binding sites, while ATP binds at a separate site. AMP and phosphoenolpyruvate/oxaloacetic acid operate independently, with AMP activating Xfp2 and phosphoenolpyruvate/oxaloacetic acid inhibiting the activated enzyme | Cryptococcus neoformans |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Cryptococcus neoformans | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | existence of both substrate cooperativity for all three substrates and allosteric regulation through the binding of effector molecules at sites separate from the active site | Cryptococcus neoformans | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Xf2 | - |
Cryptococcus neoformans |
xylulose 5-phosphate/fructose 6-phosphate phosphoketolase | - |
Cryptococcus neoformans |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.6 | - |
pH not specified in the publication, temperature not specified in the publication | Cryptococcus neoformans | ATP |