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Literature summary for 4.1.2.20 extracted from

  • Bhaskar, V.; Kumar, M.; Manicka, S.; Tripathi, S.; Venkatraman, A.; Krishnaswamy, S.
    Identification of biochemical and putative biological role of a xenolog from Escherichia coli using structural analysis (2011), Proteins, 79, 1132-1142.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21 (DE3) cells Escherichia coli

Crystallization (Commentary)

Crystallization (Comment) Organism
micro batch method, cocrystallization of YagE with 2-keto-3-deoxy galactonate and with pyruvate and glyceraldehyde in 100 mM HEPES pH 6.5, 200 mM MgCl2, 15% (w/v) PEG 3350, 50 mM pyruvate, and 50 mM glyceraldehyde Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli P75682
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-dehydro-3-deoxy-D-galactonate
-
Escherichia coli ?
-
?
pyruvate + glyceraldehyde
-
Escherichia coli ?
-
?

Subunits

Subunits Comment Organism
tetramer x-ray crystallography Escherichia coli

Synonyms

Synonyms Comment Organism
2-keto-3-deoxy gluconate aldolase
-
Escherichia coli
KDG aldolase
-
Escherichia coli
KDGA
-
Escherichia coli
YagE
-
Escherichia coli

General Information

General Information Comment Organism
physiological function overexpression of YagE increases cell viability in the presence of certain bactericidal antibiotics, indicating a putative biological role of YagE as a prophage encoded virulence factor enabling the survival of bacteria in the presence of certain antibiotics Escherichia coli