Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 4.1.2.14 extracted from

  • Braga, R.; Hecquet, L.; Blonski, C.
    Slow-binding inhibition of 2-keto-3-deoxy-6-phosphogluconate (KDPG) aldolase (2004), Bioorg. Med. Chem., 12, 2965-2972.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2,4-dioxo-4-phenylbutanoic acid
-
Escherichia coli
2,4-dioxo-4-[2-(trifluoromethyl)phenyl]butanoic acid
-
Escherichia coli
2,4-dioxo-4-[3-(trifluoromethyl)phenyl]butanoic acid
-
Escherichia coli
2,4-dioxo-4-[4-(trifluoromethyl)phenyl]butanoic acid
-
Escherichia coli
4-(3-methoxyphenyl)-2,4-dioxobutanoic acid
-
Escherichia coli
4-(4-methoxyphenyl)-2,4-dioxobutanoic acid
-
Escherichia coli
acetylpyruvic acid
-
Escherichia coli

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.06
-
2-dehydro-3-deoxy-D-gluconate 6-phosphate pH 7.6, 25°C Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-dehydro-3-deoxy-D-gluconate 6-phosphate
-
Escherichia coli pyruvate + D-glyceraldehyde 3-phosphate
-
?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.03
-
2,4-dioxo-4-[3-(trifluoromethyl)phenyl]butanoic acid pH 7.6, 25°C Escherichia coli
0.04
-
2,4-dioxo-4-[2-(trifluoromethyl)phenyl]butanoic acid pH 7.6, 25°C Escherichia coli
0.07
-
2,4-dioxo-4-phenylbutanoic acid pH 7.6, 25°C Escherichia coli
0.075
-
4-(3-methoxyphenyl)-2,4-dioxobutanoic acid pH 7.6, 25°C Escherichia coli
0.18
-
4-(4-methoxyphenyl)-2,4-dioxobutanoic acid pH 7.6, 25°C Escherichia coli
0.25
-
acetylpyruvic acid pH 7.6, 25°C Escherichia coli
0.38
-
2,4-dioxo-4-[4-(trifluoromethyl)phenyl]butanoic acid pH 7.6, 25°C Escherichia coli