Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 4.1.1.97 extracted from

  • Lee, I.R.; Yang, L.; Sebetso, G.; Allen, R.; Doan, T.H.; Blundell, R.; Lui, E.Y.; Morrow, C.A.; Fraser, J.A.
    Characterization of the complete uric acid degradation pathway in the fungal pathogen Cryptococcus neoformans (2013), PLoS ONE, 8, e64292.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.1.1.97

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate Cryptococcus neoformans
-
 (S)-allantoin + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Cryptococcus neoformans
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
-
 Cryptococcus neoformans (S)-allantoin + CO2
-
 ?

Synonyms

Synonyms Comment Organism
OHCU decarboxylase
-
 Cryptococcus neoformans
Uro3
-
 Cryptococcus neoformans

General Information

General Information Comment Organism
malfunction an uro3 deletion mutant exhibits growth defects on uric acid, but displays wild type growth on allantoin, urea and ammonium Cryptococcus neoformans
physiological function the enzyme is dispensable for virulence Cryptococcus neoformans