Literature summary for 4.1.1.90 extracted from

Walker, C.S.; Shetty, R.P.; Clark, K.; Kazuko, S.G.; Letsou, A.; Olivera, B.M.; Bandyopadhyay, P.K.
On a potential global role for vitamin K-dependent gamma-carboxylation in animal systems. Evidence for a gamma-glutamyl carboxylase in Drosophila (2001), J. Biol. Chem., 276, 7769-7774.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Drosophila melanogaster	one of the most distinctive of the extracellular post-translational modifications is the vitamin K-dependent gamma-carboxylation of glutamate residues to give gamma-carboxyglutamate	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Drosophila melanogaster	Q9W0C4	schematic of amino acid homology between human and the Drosophila gamma-glutamyl carboxylase shown	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
S2 cell	-	Drosophila melanogaster	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
conantokin G + CO2 + O2 + vitamin K hydroquinone	poorly carboxylated	Drosophila melanogaster	? + vitamin K epoxide + H2O	-	?
FLEEL + CO2 + O2 + vitamin K hydroquinone	-	Drosophila melanogaster	? + vitamin K epoxide + H2O	-	?
GKDRLTQMKRILKQRGNKARGEEELY + CO2 + O2 + vitamin K hydroquinone	-	Drosophila melanogaster	? + vitamin K epoxide + H2O	-	?
L-glutamate + CO2 + O2 + vitamin K hydroquinone	-	Drosophila melanogaster	gamma-carboxy L-glutamate + vitamin K epoxide + H2O	-	?
additional information	one of the most distinctive of the extracellular post-translational modifications is the vitamin K-dependent gamma-carboxylation of glutamate residues to give gamma-carboxyglutamate	Drosophila melanogaster	?	-	?

Synonyms

Synonyms	Comment	Organism
gamma-glutamyl carboxylase	-	Drosophila melanogaster
glutamate carboxylase	-	Drosophila melanogaster

Cofactor

Cofactor	Comment	Organism	Structure
vitamin K	phytonadione	Drosophila melanogaster

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Release 2023.1 (January 2023)