Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum | potential impact of quality control components on carboxylation, which occurs in the endoplasmic reticulum during the secretion of vitamin KĀdependent proteins | Homo sapiens | 5783 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | uses the oxygenation of vitamin K to convert glutamyl residues to gamma-carboxylated glutamyl residues in vitamin KĀdependent proteins | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
gamma-carboxylated glutamyl containing vitamin K-dependent protein + vitamin K epoxide + H2O | - |
Homo sapiens | ? | - |
? | |
glutamyl containing vitamin K-dependent protein + CO2 + vitamin K hydroquinone + O2 | propeptide binding increases carboxylase affinity for the Glu substrate, and the coordinated binding of the vitamin KĀdependent propeptide and Glu substrate increase carboxylase affinity for vitamin K and activity, possibly through a mechanism of substrate-assisted catalysis. The propeptide adjacent to the Gla domain is cleaved subsequently to carboxylation. The carboxylase uses the energy of vitamin K hydroquinone oxygenation to convert glutamyl residues to gamma-carboxylated glutamyl residues in vitamin KĀdependent proteins. During carboxylation, the vitamin K hydroquinone cofactor is oxidized to a vitamin K epoxide product. The carboxylase itself is also a vitamin KĀdependent protein and carboxylase carboxylation may be important in regulating the overall process of vitamin KĀdependent protein carboxylation. All vitamin KĀdependent proteins contain multiple glutamyl residues that undergo carboxylation, which is accomplished by a processive mechanism. A single binding event between carboxylase and vitamin KĀdependent protein can give rise to all of the glutamyl to gamm-carboxylated glutamyl conversions in the vitamin KĀdependent protein. Carboxylation is limited to the glutamyl residue residing within the Gla domain | Homo sapiens | ? | - |
? | |
additional information | uses the oxygenation of vitamin K to convert glutamyl residues to gamma-carboxylated glutamyl residues in vitamin KĀdependent proteins | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
glutamate carboxylase | - |
Homo sapiens |
VKD carboxylase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
vitamin K | the carboxylase uses the energy of vitamin K hydroquinone oxygenation to convert glutamyl residues to gamma-carboxylated glutamyl residues in vitamin KĀdependent proteins. During carboxylation, the vitamin K hydroquinone cofactor is oxidized to a vitamin K epoxide product | Homo sapiens |