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Literature summary for 4.1.1.9 extracted from

  • Zhou, W.; Tu, Y.; Simpson, P.J.; Kuhajda, F.P.
    Malonyl-CoA decarboxylase inhibition is selectively cytotoxic to human breast cancer cells (2009), Oncogene, 28, 2979-2987.
    View publication on PubMed
Search for more literature for 4.1.1.9

Application

Application Comment Organism
medicine MCD is a potential novel target for cancer treatment Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
5-[(morpholine-4-carbonyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenyl]-amino]-pentanoic acid methyl ester 30% inhibition at 0.08 mg/ml, 50% inhibition at approximately 0.16 mg/ml Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
breast cancer cell
-
 Homo sapiens
-
MCF-7 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Malonyl-CoA
-
 Homo sapiens Acetyl-CoA + CO2
-
 ?

Synonyms

Synonyms Comment Organism
MCD
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function malonyl-CoA is both a substrate for fatty acid synthase and an inhibitor of fatty acid oxidation acting as a metabolic switch between anabolic fatty acid synthesis and catabolic fatty acid oxidation Homo sapiens