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Literature summary for 4.1.1.9 extracted from

  • Cheng, J.F.; Huang, Y.; Penuliar, R.; Nishimoto, M.; Liu, L.; Arrhenius, T.; Yang, G.; Oleary, E.; Barbosa, M.; Barr, R.; Dyck, J.R.; Lopaschuk, G.D.; Nadzan, A.M.
    Discovery of potent and orally available malonyl-CoA decarboxylase inhibitors as cardioprotective agents (2006), J. Med. Chem., 49, 4055-4058.
    View publication on PubMed
Search for more literature for 4.1.1.9

Inhibitors

Inhibitors Comment Organism Structure
1,3-dimethyl-1-(2-methylpropyl)butyl 3-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]butanoate
-
 Rattus norvegicus
1,3-dimethyl-1-(2-methylpropyl)butyl N-([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)-beta-alaninate
-
 Rattus norvegicus
1-ethyl-1-methylpropyl (3S)-3-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]butanoate
-
 Rattus norvegicus
1-ethyl-1-methylpropyl N-([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)-beta-alaninate
-
 Rattus norvegicus
ethyl 3-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]propanoate
-
 Rattus norvegicus
ethyl 4-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]butanoate
-
 Rattus norvegicus
ethyl [((5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl)carbonyl)amino]acetate
-
 Rattus norvegicus
N-(1-methylethyl)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide
-
 Rattus norvegicus
N-(1-methylethyl)-N-(2-methylpropyl)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide
-
 Rattus norvegicus
N-(3,3-dimethylbutyl)-N-(2-methylpropyl)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide
-
 Rattus norvegicus
N-(3-tert-butoxypropyl)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide
-
 Rattus norvegicus
N-(6-methylheptyl)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide
-
 Rattus norvegicus
N-heptyl-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide
-
 Rattus norvegicus
N-methyl-N-(1-methylethyl)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide
-
 Rattus norvegicus
N-[3-[bis(1-methylethyl)amino]-3-oxopropyl]-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide
-
 Rattus norvegicus
tert-butyl (3R)-3-[(((5R)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl)carbonyl)amino]butanoate
-
 Rattus norvegicus
tert-butyl (3R)-3-[(((5S)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl)carbonyl)amino]butanoate
-
 Rattus norvegicus
tert-butyl (3R)-3-[((5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl)carbonyl)amino]butanoate
-
 Rattus norvegicus
tert-butyl (3R)-5-methyl-3-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]hexanoate
-
 Rattus norvegicus
tert-butyl (3S)-3-[(((5R)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl)carbonyl)amino]butanoate
-
 Rattus norvegicus
tert-butyl (3S)-3-[(((5S)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl)carbonyl)amino]butanoate
-
 Rattus norvegicus
tert-butyl (3S)-3-[((5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl)carbonyl)amino]butanoate
-
 Rattus norvegicus
tert-butyl (3S)-5-methyl-3-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]hexanoate
-
 Rattus norvegicus
tert-butyl 3-(5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-4,5-dihydroisoxazole-3-carboxamido)butanoate i.e. CBM-301940 Rattus norvegicus
tert-butyl 3-[((5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl)carbonyl)amino]butanoate
-
 Rattus norvegicus
tert-butyl 3-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]propanoate
-
 Rattus norvegicus
tert-butyl 5-methyl-3-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]hexanoate
-
 Rattus norvegicus
tert-butyl N-([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)leucinate
-
 Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Malonyl-CoA
-
 Rattus norvegicus Acetyl-CoA + CO2
-
 ?

Synonyms

Synonyms Comment Organism
MCD
-
 Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000005
-
-
 Rattus norvegicus 1-ethyl-1-methylpropyl (3S)-3-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]butanoate
0.000005
-
-
 Rattus norvegicus tert-butyl (3S)-3-[(((5R)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl)carbonyl)amino]butanoate
0.000007
-
-
 Rattus norvegicus 1-ethyl-1-methylpropyl N-([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)-beta-alaninate
0.000007
-
-
 Rattus norvegicus tert-butyl (3S)-3-[((5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl)carbonyl)amino]butanoate
0.000008
-
-
 Rattus norvegicus tert-butyl (3R)-3-[(((5R)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl)carbonyl)amino]butanoate
0.00001
-
-
 Rattus norvegicus tert-butyl (3R)-3-[((5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl)carbonyl)amino]butanoate
0.000015
-
-
 Rattus norvegicus tert-butyl (3S)-5-methyl-3-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]hexanoate
0.000017
-
-
 Rattus norvegicus N-[3-[bis(1-methylethyl)amino]-3-oxopropyl]-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide
0.000023
-
-
 Rattus norvegicus tert-butyl 3-[((5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl)carbonyl)amino]butanoate
0.000028
-
-
 Rattus norvegicus N-(3-tert-butoxypropyl)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide
0.000028
-
-
 Rattus norvegicus N-(6-methylheptyl)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide
0.00003
-
-
 Rattus norvegicus tert-butyl 5-methyl-3-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]hexanoate
0.000031
-
-
 Rattus norvegicus tert-butyl 3-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]propanoate
0.000037
-
-
 Rattus norvegicus 1,3-dimethyl-1-(2-methylpropyl)butyl 3-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]butanoate
0.000045
-
-
 Rattus norvegicus tert-butyl (3R)-5-methyl-3-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]hexanoate
0.00006
-
-
 Rattus norvegicus N-heptyl-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide
0.00009
-
-
 Rattus norvegicus 1,3-dimethyl-1-(2-methylpropyl)butyl N-([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)-beta-alaninate
0.000113
-
-
 Rattus norvegicus tert-butyl N-([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)leucinate
0.000136
-
-
 Rattus norvegicus tert-butyl (3S)-3-[(((5S)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl)carbonyl)amino]butanoate
0.000137
-
-
 Rattus norvegicus N-(1-methylethyl)-N-(2-methylpropyl)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide
0.000168
-
-
 Rattus norvegicus tert-butyl (3R)-3-[(((5S)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl)carbonyl)amino]butanoate
0.000421
-
-
 Rattus norvegicus ethyl 4-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]butanoate
0.000463
-
-
 Rattus norvegicus ethyl 3-[([5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl]carbonyl)amino]propanoate
0.000489
-
-
 Rattus norvegicus N-(3,3-dimethylbutyl)-N-(2-methylpropyl)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide
0.000676
-
-
 Rattus norvegicus N-methyl-N-(1-methylethyl)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide
0.000801
-
-
 Rattus norvegicus N-(1-methylethyl)-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazole-3-carboxamide
0.001767
-
-
 Rattus norvegicus ethyl [((5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-4,5-dihydroisoxazol-3-yl)carbonyl)amino]acetate