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Literature summary for 4.1.1.9 extracted from
- Liver malonyl-CoA decarboxylase (1973), Biochim. Biophys. Acta, 309, 457-465.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| DL-carnitine | stimulates | Bos taurus |  |
| phosphate | activates | Bos taurus | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| acetyl-CoA | - |
Bos taurus | |
| palmitoyl-CoA | noncompetitive | Bos taurus | |
| propionyl-CoA | - |
Bos taurus | |
| pyridoxal 5'-phosphate | partly competitive | Bos taurus | |
| Vanillin | - |
Bos taurus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.065 | - |
malonyl-CoA | in presence of 150 mM PO43- | Bos taurus | |
| 0.146 | - |
malonyl-CoA | in presence of 40 mM PO43- | Bos taurus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | matrix space | Bos taurus | 5739 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 250000 | - |
gel filtration | Bos taurus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Bos taurus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 206 | - |
- |
Bos taurus |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -20°C, one-third of the enzyme activity disappears after 4 months | Bos taurus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Malonyl-CoA | - |
Bos taurus | Acetyl-CoA + CO2 | - |
? | |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 49 | - |
50% loss of activity after 2 min | Bos taurus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 5 | - |
2 optima: pH 5 and pH 9 | Bos taurus |
| 9 | - |
2 optima: pH 5 and pH 9 | Bos taurus |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 5 | 9 | 2 optima at pH 5 and at pH 9, minimal activity at pH 6-7 | Bos taurus |
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Release 2023.1 (January 2023)
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