Literature summary for 4.1.1.72 extracted from

Dickinson, J.R.; Harrison, S.J.; Dickinson, J.A.; Hewlins, M.J.
An investigation of the metabolism of isoleucine to active amyl alcohol in Saccharomyces cerevisiae (2000), J. Biol. Chem., 275, 10937-10942.

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Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	Q07471	-	-

Synonyms

Synonyms	Comment	Organism
THI3	-	Saccharomyces cerevisiae
YDL080c	-	Saccharomyces cerevisiae

General Information

General Information	Comment	Organism
physiological function	metabolic routes between isoleucine and active amyl alcohol all involve the initial decarboxylation of isoleucine to 2-oxo-3-methylvalerate and subsequent decarboxylation to 2-methylbutanoate. One of the decarboxylases encoded by PDC1, PDC5, PDC6, YDL080c, or YDR380w must be present to allow yeast to utilize 2-oxo-3-methylvalerate. Any one of this family of decarboxylases is sufficient to allow the catabolism of isoleucine to active amyl alcohol	Saccharomyces cerevisiae
physiological function	metabolic routes between isoleucine and active amyl alcohol all involve the initial decarboxylation of isoleucine to 2-oxo-3-methylvalerate and subsequent decarboxylation to 2-methylbutanoate. One of the decarboxylases encoded by PDC1, PDC5, PDC6, YDL080c, or YDR380w must be present to allow yeast to utilize 2-oxo-3-methylvalerate. Any one of this family of decarboxylases is sufficient to allow the catabolism of isoleucine to active amyl alcohol. In leucine catabolism, the enzyme encoded by YDL080c is solely responsible for the decarboxylation of alpha-ketoisocaproate, whereas in valine catabolism any one of the isozymes of pyruvate decarboxylase will decarboxylate 2-oxoisovalerate	Saccharomyces cerevisiae

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Release 2023.1 (January 2023)