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Literature summary for 4.1.1.72 extracted from

  • Kean, E.A.; Morrison, E.Y.St.A.
    Isolation of a branched-chain alpha-keto acid decarboxylase from rat liver (1979), Biochim. Biophys. Acta, 567, 12-17.
    View publication on PubMed
Search for more literature for 4.1.1.72

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.87
-
 3-methyl-2-oxopentanoate 25°C, pH 7.2 Rattus norvegicus
2
-
 2-Oxoisohexanoate 25°C, pH 7.2 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Rattus norvegicus 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3-methyl-2-oxopentanoate Rattus norvegicus
-
 CO2 + 2-methylbutanal
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 enzyme may be a component of an enzyme complex named alpha-ketoisocaproate:alpha-keto-beta-methylvalerate dehydrogenase
-

Purification (Commentary)

Purification (Comment) Organism
-
 Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-oxoisohexanoate 38% of the activity with L-3-methyl-2-oxopentanoate Rattus norvegicus CO2 + isopentanal
-
 ?
3-methyl-2-oxopentanoate
-
 Rattus norvegicus CO2 + 2-methylbutanal
-
 ?
L-3-methyl-2-oxopentanoate
-
 Rattus norvegicus CO2 + 2-methylbutanal
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
 assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.2
-
 assay at Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
thiamine diphosphate stimulates moderately Rattus norvegicus