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Literature summary for 4.1.1.64 extracted from

  • Liu, W.; Rogers, C.J.; Fisher, A.J.; Toney, M.D.
    Aminophosphonate inhibitors of dialkylglycine decarboxylase: structural basis for slow binding inhibition (2002), Biochemistry, 41, 12320-12328.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
in complex with different aminophosphonate inhibitors Burkholderia cepacia

Inhibitors

Inhibitors Comment Organism Structure
(R)-1-amino-1-methylpropanephosphonate
-
Burkholderia cepacia
(R)-1-amino-1-phenylethanephosphonate
-
Burkholderia cepacia
(R)-1-aminoethanephosphonate
-
Burkholderia cepacia
(S)-1-aminoethanephosphonate
-
Burkholderia cepacia
1-aminocyclopentanephosphonate
-
Burkholderia cepacia

Organism

Organism UniProt Comment Textmining
Burkholderia cepacia P16932
-
-

Reaction

Reaction Comment Organism Reaction ID
2,2-dialkylglycine + pyruvate = dialkyl ketone + CO2 + L-alanine kinetics of inhibition Burkholderia cepacia

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.1
-
(S)-1-aminoethanephosphonate pH 7.8, homologous to D-alanine Burkholderia cepacia
4.9
-
(R)-1-amino-1-methylpropanephosphonate pH 7.8, homologous to L-isovaline Burkholderia cepacia
6
-
1-aminocyclopentanephosphonate pH 7.8, homologous to aminocyclopropane carboxylate Burkholderia cepacia
13
-
(R)-1-amino-1-phenylethanephosphonate pH 7.8, homologous to L-phenylglycine Burkholderia cepacia
19
-
(R)-1-aminoethanephosphonate pH 7.8, homologous to L-alanine Burkholderia cepacia