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Literature summary for 4.1.1.6 extracted from

  • Bentley, R.; Thiessen, C.P.
    Biosynthesis of itaconic acid in Aspergillus terreus (1957), J. Biol. Chem., 226, 703-720.
    View publication on PubMed
Search for more literature for 4.1.1.6

General Stability

General Stability Organism
no loss of activity after dialysis for 2 h at 0°C against 0.05 M phosphate buffer, pH 7. Inactivation after 15 h Aspergillus terreus

Inhibitors

Inhibitors Comment Organism Structure
Cu2+
-
 Aspergillus terreus
Fe2+
-
 Aspergillus terreus
Fluorocitrate inhibits citrate decarboxylation, no inhibition of decarboxylation of cis-aconitate Aspergillus terreus
Hg2+
-
 Aspergillus terreus
L-Isocitric acid competitive inhibition Aspergillus terreus
p-chloromercuribenzoate
-
 Aspergillus terreus
trans-aconitate slight inhibition of decarboxylation of citrate Aspergillus terreus
Zn2+
-
 Aspergillus terreus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cis-aconitate Aspergillus terreus enzyme is involved in biosynthesis of itaconate ?
-
 ?

Organism

Organism UniProt Comment Textmining
Aspergillus terreus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Aspergillus terreus

Source Tissue

Source Tissue Comment Organism Textmining
mycelium
-
 Aspergillus terreus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cis-aconitate no activity with trans-aconitate Aspergillus terreus itaconate + CO2
-
 ?
cis-aconitate enzyme is involved in biosynthesis of itaconate Aspergillus terreus ?
-
 ?
citrate
-
 Aspergillus terreus itaconate + CO2
-
 ?
D-isocitrate
-
 Aspergillus terreus itaconate + CO2
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5.6 6
-
 Aspergillus terreus