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Literature summary for 4.1.1.57 extracted from

  • Stevenson, D.E.; Akhtar, M.; Gani, D.
    L-Methionine decarboxylase from Dryopteris filix-mas: purification, characterization, substrate specificity, abortive transamination of the coenzyme, and stereochemical courses of substrate decarboxylation and coenzyme transamination (1990), Biochemistry, 29, 7631-7647.
    View publication on PubMed
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Activating Compound

Activating Compound Comment Organism Structure
detergent required Dryopteris filix-mas

Inhibitors

Inhibitors Comment Organism Structure
D-Met i.e. (2R)-Met Dryopteris filix-mas

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
48
-
 L-Met
-
 Dryopteris filix-mas
124
-
 L-Leu
-
 Dryopteris filix-mas
147
-
 L-norvaline
-
 Dryopteris filix-mas
153
-
 L-Ile
-
 Dryopteris filix-mas
155
-
 L-norleucine
-
 Dryopteris filix-mas
1000
-
 S-ethyl-L-Cys
-
 Dryopteris filix-mas
1100
-
 L-Val
-
 Dryopteris filix-mas

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Dryopteris filix-mas 16020
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
57000
-
 2 * 57000, SDS-PAGE Dryopteris filix-mas
100000
-
 gel filtration Dryopteris filix-mas

Organism

Organism UniProt Comment Textmining
Dryopteris filix-mas
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Dryopteris filix-mas

Source Tissue

Source Tissue Comment Organism Textmining
leaf frond Dryopteris filix-mas
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
20
-
-
 Dryopteris filix-mas

Storage Stability

Storage Stability Organism
-30°C, stable for several months Dryopteris filix-mas

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-Ile 45% of the activity with L-Met Dryopteris filix-mas 2-Methylbutylamine + CO2
-
 ?
L-Leu 59% of the activity with L-Met Dryopteris filix-mas 3-Methylbutylamine + CO2
-
 ?
L-Met
-
 Dryopteris filix-mas 3-Methylthiopropanamine + CO2
-
 ?
L-norleucine 51% of the activity with L-Met Dryopteris filix-mas pentanamine + CO2
-
 ?
L-Norvaline 78% of the activity with L-Met Dryopteris filix-mas Butylamine + CO2
-
 ?
L-Val as active as L-Met Dryopteris filix-mas 2-Methylpropylamine + CO2
-
 ?
S-Ethyl-L-Cys as active as L-Met Dryopteris filix-mas 2-Ethylthioethanamine + CO2
-
 ?

Subunits

Subunits Comment Organism
dimer 2 * 57000, SDS-PAGE Dryopteris filix-mas

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
50
-
 L-Met at pH 4.5 and below Dryopteris filix-mas
100
-
 L-Met at pH 4.8 Dryopteris filix-mas

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5
-
-
 Dryopteris filix-mas

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate coenzyme Dryopteris filix-mas