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Literature summary for 4.1.1.57 extracted from

  • Misono, H.; Kawabata, Y.; Toyosato, M.; Yamamoto, T.; Soda, K.
    Purification and properties of L-methionine decarboxylase of Streptomyces sp. (1980), Bull. Inst. Chem. Res. Kyoto Univ., 58, 323-333.
No PubMed abstract available

Inhibitors

Inhibitors Comment Organism Structure
Ag2SO4
-
Streptomyces sp.
CuSO4
-
Streptomyces sp.
cycloserine
-
Streptomyces sp.
cysteine
-
Streptomyces sp.
D-Met
-
Streptomyces sp.
FeSO4
-
Streptomyces sp.
HgCl2
-
Streptomyces sp.
Penicillamine
-
Streptomyces sp.
phenylhydrazine
-
Streptomyces sp.

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
5
-
L-Met
-
Streptomyces sp.
16
-
L-norleucine
-
Streptomyces sp.
44
-
S-ethyl-L-Cys
-
Streptomyces sp.

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
130000
-
gel filtration Streptomyces sp.

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-Met Streptomyces sp. induced by L-Met ?
-
?

Organism

Organism UniProt Comment Textmining
Streptomyces sp.
-
strain 590, strain 591, strain 592
-

Purification (Commentary)

Purification (Comment) Organism
-
Streptomyces sp.

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
29.7
-
-
Streptomyces sp.

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DL-Homocysteine 24% of the activity with L-Met Streptomyces sp. 3-Thiopropanamine + CO2
-
?
L-Ethionine 7.8% of the activity with L-Met Streptomyces sp. 3-Ethylthiopropanamine + CO2
-
?
L-Ethionine 19% of the activity with L-Met Streptomyces sp. 3-Ethylthiopropanamine + CO2
-
?
L-Ile 24.2% of the activity with L-Met Streptomyces sp. 2-Methylbutylamine + CO2
-
?
L-Ile 29% of the activity with L-Met Streptomyces sp. 2-Methylbutylamine + CO2
-
?
L-Leu 15% of the activity with L-Met Streptomyces sp. 3-Methylbutylamine + CO2
-
?
L-Leu 5.3% of the activity with L-Met Streptomyces sp. 3-Methylbutylamine + CO2
-
?
L-Met
-
Streptomyces sp. 3-Methylthiopropanamine + CO2
-
?
L-Met induced by L-Met Streptomyces sp. ?
-
?
L-norleucine 45.3% of the activity with L-Met Streptomyces sp. pentanamine + CO2
-
?
L-norleucine 63% of the activity with L-Met Streptomyces sp. pentanamine + CO2
-
?
L-Norvaline 22% of the activity with L-Met Streptomyces sp. Butylamine + CO2
-
?
L-Norvaline 34% of the activity with L-Met Streptomyces sp. Butylamine + CO2
-
?
S-Ethyl-L-Cys 29.3% of the activity with L-Met Streptomyces sp. 2-Ethylthioethanamine + CO2
-
?
S-Ethyl-L-Cys 61% of the activity with L-Met Streptomyces sp. 2-Ethylthioethanamine + CO2
-
?
S-Methyl-L-Cys 13% of the activity with L-Met Streptomyces sp. 2-Methylthioethanamine + CO2
-
?
S-Methyl-L-Met 13% of the activity with L-Met Streptomyces sp. 3-Dimethylthiopropanamine + CO2
-
?

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
45
-
pH 7.2, stable up to Streptomyces sp.
50
-
pH 5.5, stable up to Streptomyces sp.

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.4
-
-
Streptomyces sp.

pH Range

pH Minimum pH Maximum Comment Organism
4.2 8.5 pH 4.2: about 35% of maximal activity, pH 8.5: about 45% of maximal activity Streptomyces sp.

pH Stability

pH Stability pH Stability Maximum Comment Organism
4.5 6 stable in the range Streptomyces sp.

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate stimulates Streptomyces sp.