Literature summary for 4.1.1.50 extracted from

Kim, J.S.; Kim, T.L.; Kim, K.C.; Choe, C.; Chung, H.W.; Cho, E.W.; Kim, I.G.
S-Adenosylmethionine decarboxylase partially regulates cell growth of HL-60 cells by controlling the intracellular ROS level: Early senescence and sensitization to gamma-radiation (2006), Arch. Biochem. Biophys., 456, 58-70.

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Protein Variants

Protein Variants	Comment	Organism
additional information	suppression of enzyme expression in HL-60 cells by RNAi results in overproduction of reactive oxygen species, leading to growth defect and partial cell death. Reactive oxygen species is caused by a decrease of the total glutathione and the ratio of reduced to oxidized glutathione, and by an increase of the intracellular iron uptake	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P17707	-	-

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Release 2023.1 (January 2023)