Activating Compound | Comment | Organism | Structure |
---|---|---|---|
1,15-diamino-4,12-diazapentadecane | - |
Onchocerca volvulus | |
1,5-Diaminopentane | 57% of activation by putrescine | Onchocerca volvulus | |
1,6-diaminohexane | 58% of activation by putrescine | Onchocerca volvulus | |
1,7-Diaminoheptane | 45% of activation by putrescine | Onchocerca volvulus | |
33-003 | - |
Onchocerca volvulus | |
N1-acetylspermidine | 60% of activation by putrescine | Onchocerca volvulus | |
PMW-2000-11-13-5 | - |
Onchocerca volvulus | |
putrescine | - |
Onchocerca volvulus | |
spermidine | 82% of activation by putrescine | Onchocerca volvulus | |
spermine | 13% of activation by putrescine | Onchocerca volvulus | |
YZ-33-046 | - |
Onchocerca volvulus | |
YZ-33-050C | - |
Onchocerca volvulus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
BW-1 | 85% inhibition at 2 mM, in presence of 2 mM putrescine, degree of inhibition depends on actual putrescine abundance | Homo sapiens | |
BW-1 | 99% inhibition at 2 mM, in presence of 2 mM putrescine, degree of inhibition depends on actual putrescine abundance | Onchocerca volvulus | |
MDL 27695 | 44% inhibition at 2 mM, in presence of 2 mM putrescine | Homo sapiens | |
MDL 27695 | 86% inhibition at 2 mM, in presence of 2 mM putrescine | Onchocerca volvulus | |
PMW-2000-11-13-1 | 52% inhibition at 2 mM, in presence of 2 mM putrescine | Homo sapiens | |
PMW-2000-11-13-1 | 97% inhibition at 2 mM, in presence of 2 mM putrescine | Onchocerca volvulus | |
RHW-17-69-75 | 45% inhibition at 2 mM, in presence of 2 mM putrescine | Homo sapiens | |
RHW-17-69-75 | 97% inhibition at 2 mM, in presence of 2 mM putrescine | Onchocerca volvulus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Onchocerca volvulus | - |
- |
- |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
1.3 | - |
without activator | Onchocerca volvulus |
8 | - |
plus 2 mM 1,15-diamino-4,12-diazapentadecane | Onchocerca volvulus |
8 | - |
plus 2 mM 33-003 | Onchocerca volvulus |
19 | - |
pus 2 mM YZ-33-050C | Onchocerca volvulus |
26 | - |
plus 2 mM PMW-2000-11-13-5 | Onchocerca volvulus |
46 | - |
plus 2 mM YZ-33-046 | Onchocerca volvulus |
79 | - |
plus 2 mM putrescine | Onchocerca volvulus |
121 | - |
plus 2 mM YZ-33-050C | Homo sapiens |
148 | - |
plus 2 mM 33-003 | Homo sapiens |
152 | - |
plus 2 mM PMW-2000-11-13-5 | Homo sapiens |
176 | - |
plus 2 mM YZ-33-046 | Homo sapiens |
180 | - |
plus 2 mM 1,15-diamono-4,12-diazapentadecane | Homo sapiens |
410 | - |
plus 2 mM putrescine | Homo sapiens |