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Literature summary for 4.1.1.50 extracted from

  • Shantz, L.M.; Stanley, B.A.; Secrist III, J.A.; Pegg, A.E.
    Purification of human S-adenosylmethionine decarboxylase expressed in Escherichia coli and use of this protein to investigate the mechanism of inhibition by the irreversible inhibitors, 5'-deoxy-5'-[(3-hydrazinopropyl)methylamino]adenosine and 5'-[[(Z)-4-amino-2-butenyl]methylamino]-5'-deoxyadenosine (1992), Biochemistry, 31, 6848-6855.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
pyruvate cofactor Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
5'-Deoxy-5'-[(3-hydrazinopropyl)methylamino]adenosine irreversible Homo sapiens
5'-{[(Z)-4-Amino-2-butenyl]methylamino}-5'-deoxyadenosine irreversible; the inhibitor leads to transamination of the pyruvate prosthetic group Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
large-scale Homo sapiens

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.992
-
-
Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine
-
Homo sapiens (5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
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