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Literature summary for 4.1.1.5 extracted from

  • Monnet, C.; Nardi, M.; Hols, P.; Gulea, M.; Corrieu, G.; Monnet, V.
    Regulation of branched-chain amino acid biosynthesis by alpha-acetolactate decarboxylase in Streptococcus thermophilus (2003), Lett. Appl. Microbiol., 36, 399-405.
    View publication on PubMed
Search for more literature for 4.1.1.5

Activating Compound

Activating Compound Comment Organism Structure
isoleucine requirement for branched-chain amino acids, control of the pool of alpha-acetolactate by valine, leucine and isoleucine via allosteric activation, valine is more stimulatory than leucine and isoleucine Streptococcus thermophilus
leucine requirement for branched-chain amino acids, control of the pool of alpha-acetolactate by valine, leucine and isoleucine via allosteric activation, valine is more stimulatory than leucine and isoleucine Streptococcus thermophilus
valine requirement for branched-chain amino acids, control of the pool of alpha-acetolactate by valine, leucine and isoleucine via allosteric activation, valine is more stimulatory than leucine and isoleucine Streptococcus thermophilus

Cloned(Commentary)

Cloned (Comment) Organism
aldC gene, expression in Escherichia coli Streptococcus thermophilus

Protein Variants

Protein Variants Comment Organism
additional information alpha-acetolactate decarboxylase-deficient mutant TIL865 Streptococcus thermophilus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(S)-2-hydroxy-2-methyl-3-oxobutanoate Streptococcus thermophilus regulates leucine and valine biosynthesis by diverting the flux of alpha-acetolactate towards acetoin when branched-chain amino acids are present at a high concentration, involved in catabolism of pyruvate to acetoin, but less important function in vivo (R)-acetoin + CO2
-
 ?
(S)-2-hydroxy-2-methyl-3-oxobutanoate Streptococcus thermophilus CNRZ385 regulates leucine and valine biosynthesis by diverting the flux of alpha-acetolactate towards acetoin when branched-chain amino acids are present at a high concentration, involved in catabolism of pyruvate to acetoin, but less important function in vivo (R)-acetoin + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Streptococcus thermophilus Q8L208
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-
Streptococcus thermophilus CNRZ385 Q8L208
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-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.27
-
 culture in the presence of leucine and isoleucine Streptococcus thermophilus
0.472
-
 culture in the presence of leucine and valine Streptococcus thermophilus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-2-hydroxy-2-methyl-3-oxobutanoate
-
 Streptococcus thermophilus (R)-acetoin + CO2
-
 ?
(S)-2-hydroxy-2-methyl-3-oxobutanoate regulates leucine and valine biosynthesis by diverting the flux of alpha-acetolactate towards acetoin when branched-chain amino acids are present at a high concentration, involved in catabolism of pyruvate to acetoin, but less important function in vivo Streptococcus thermophilus (R)-acetoin + CO2
-
 ?
(S)-2-hydroxy-2-methyl-3-oxobutanoate
-
 Streptococcus thermophilus CNRZ385 (R)-acetoin + CO2
-
 ?
(S)-2-hydroxy-2-methyl-3-oxobutanoate regulates leucine and valine biosynthesis by diverting the flux of alpha-acetolactate towards acetoin when branched-chain amino acids are present at a high concentration, involved in catabolism of pyruvate to acetoin, but less important function in vivo Streptococcus thermophilus CNRZ385 (R)-acetoin + CO2
-
 ?
additional information not: alpha-acetohydroxybutyrate Streptococcus thermophilus ?
-
 ?
additional information not: alpha-acetohydroxybutyrate Streptococcus thermophilus CNRZ385 ?
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6
-
 assay at Streptococcus thermophilus