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Literature summary for 4.1.1.49 extracted from
- Cytosolic phosphoenolpyruvate carboxykinase does not solely control the rate of hepatic gluconeogenesis in the intact mouse liver (2007), Cell Metab., 5, 313-320.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | metabolic control of liver gluconeogenesis is quantified in groups of knock-out mice with varying PEPCK protein content. Livers with a 90% reduction in PEPCK content show only a 40% reduction in gluconeogenic flux, indicating a lower than expected capacity for PEPCK protein content to control gluconeogenesis. PEPCK flux correlates tightly with TCA cycle activity, suggesting that under some conditions in mice, PEPCK expression must coordinate with hepatic energy metabolism to control gluconeogenesis | Mus musculus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + oxaloacetate | - |
Mus musculus | ADP + phosphoenolpyruvate + CO2 | - |
r |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PEPCK | - |
Mus musculus |
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Release 2023.1 (January 2023)
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