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Literature summary for 4.1.1.49 extracted from

  • Trapani, S.; Linss, J.; Goldenberg, S.; Fischer, H.; Craievich, A.F.; Oliva, G.
    Crystal structure of the dimeric phosphoenolpyruvate carboxykinase (PEPCK) from Trypanosoma cruzi at 2 A resolution (2001), J. Mol. Biol., 313, 1059-1072.
    View publication on PubMed

Application

Application Comment Organism
medicine Trypanosoma cruzi is the causative agent of Chagas' disease, enzyme is a good target for the development of new anti-chagasic drugs Trypanosoma cruzi

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli Trypanosoma cruzi

Crystallization (Commentary)

Crystallization (Comment) Organism
sitting drop vapour diffusion, primitive orthorhombic crystals, space group P2(1)2(1)2(1), a : 65.97 A, b : 107.61 A, c : 179.08 A Trypanosoma cruzi

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + oxaloacetate Trypanosoma cruzi
-
ADP + phosphoenolpyruvate + CO2
-
r

Organism

Organism UniProt Comment Textmining
Trypanosoma cruzi P51058
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Trypanosoma cruzi

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + oxaloacetate
-
Trypanosoma cruzi ADP + phosphoenolpyruvate + CO2
-
r

Subunits

Subunits Comment Organism
dimer
-
Trypanosoma cruzi

Synonyms

Synonyms Comment Organism
ATP:oxaloacetate carboxylyase (transphosphorylating)
-
Trypanosoma cruzi
PEPCK
-
Trypanosoma cruzi
phosphoenolpyruvate carboxykinase
-
Trypanosoma cruzi