Literature summary for 4.1.1.45 extracted from

Garavaglia, S.; Perozzi, S.; Galeazzi, L.; Raffaelli, N.; Rizzi, M.
The crystal structure of human alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase in complex with 1,3-dihydroxyacetonephosphate suggests a regulatory link between NAD synthesis and glycolysis (2009), FEBS J., 276, 6615-6623.

Application

Application	Comment	Organism
drug development	inhibition of alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase should be explored as a possible novel therapeutic avenue for the treatment of diabetes	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
-	Homo sapiens

Crystallization (Commentary)

Crystallization (Comment)	Organism
vapour diffusion technique in hanging drop, crystal structure of human alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase in complex with the glycolytic intermediate 1,3-dihydroxyacetonephosphate (DHAP), refined to an R-factor of 0.19, 1 mM DHAP, 2% poly(ethylene glycol) (PEG 400), 0.1 M Na/Hepes pH 7.5, 2.0 M ammonium sulphate, mixed with the same amount of a protein solution at a concentration of 12.7 mg/ml, and equilibrated against 500 microL of the reservoir solution, at 20°C	Homo sapiens

Crystallization (Comment)

Organism

vapour diffusion technique in hanging drop, crystal structure of human alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase in complex with the glycolytic intermediate 1,3-dihydroxyacetonephosphate (DHAP), refined to an R-factor of 0.19, 1 mM DHAP, 2% poly(ethylene glycol) (PEG 400), 0.1 M Na/Hepes pH 7.5, 2.0 M ammonium sulphate, mixed with the same amount of a protein solution at a concentration of 12.7 mg/ml, and equilibrated against 500 microL of the reservoir solution, at 20°C

Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
1,3-dihydroxyacetonephosphate	-	Homo sapiens

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Zn2+	-	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate	Homo sapiens	-	2-aminomuconate-6-semialdehyde + CO2	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q8TDX5	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate	-	Homo sapiens	2-aminomuconate-6-semialdehyde + CO2	-	?

Synonyms

Synonyms	Comment	Organism
alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase	-	Homo sapiens
hACMSD	-	Homo sapiens