Application | Comment | Organism |
---|---|---|
medicine | quinolinate, non-enzymatically derived from 2-amino-3-(3-oxoprop-2-enyl)-but-2-enedioate is a potent endogenous excitotoxin of neuronal cells, whose elevation in brain is implicated in the pathogenesis of various neurodegenerative disorders, ACMSD is the only known enzyme that can process ACMS to a benign catabolite and thus prevent the accumulation of quinolinate | Sus scrofa |
medicine | quinolinate, non-enzymatically derived from 2-amino-3-(3-oxoprop-2-enyl)-but-2-enedioate is a potent endogenous excitotoxin of neuronal cells, whose elevation in brain is implicated in the pathogenesis of various neurodegenerative disorders, ACMSD is the only known enzyme that can process ACMS to a benign catabolite and thus prevent the accumulation of quinolinate | Mus musculus |
medicine | quinolinate, non-enzymatically derived from 2-amino-3-(3-oxoprop-2-enyl)-but-2-enedioate is a potent endogenous excitotoxin of neuronal cells, whose elevation in brain is implicated in the pathogenesis of various neurodegenerative disorders, ACMSD is the only known enzyme that can process ACMS to a benign catabolite and thus prevent the accumulation of quinolinate | Rattus norvegicus |
medicine | quinolinate, non-enzymatically derived from 2-amino-3-(3-oxoprop-2-enyl)-but-2-enedioate is a potent endogenous excitotoxin of neuronal cells, whose elevation in brain is implicated in the pathogenesis of various neurodegenerative disorders, ACMSD is the only known enzyme that can process ACMS to a benign catabolite and thus prevent the accumulation of quinolinate | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
cDNA cloning, expressed in COS7 cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
p-chloromercuribenzoate | - |
Homo sapiens | |
p-chloromercuribenzoate | - |
Mus musculus | |
p-chloromercuribenzoate | - |
Rattus norvegicus | |
p-chloromercuribenzoate | - |
Sus scrofa |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate | Sus scrofa | tryptophan-niacine pathway | 2-aminomuconate-6-semialdehyde + CO2 | - |
? | |
2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate | Mus musculus | tryptophan-niacine pathway | 2-aminomuconate-6-semialdehyde + CO2 | - |
? | |
2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate | Rattus norvegicus | tryptophan-niacine pathway | 2-aminomuconate-6-semialdehyde + CO2 | - |
? | |
2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate | Homo sapiens | tryptophan-niacine pathway | 2-aminomuconate-6-semialdehyde + CO2 | - |
? | |
2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate | Mus musculus ICR | tryptophan-niacine pathway | 2-aminomuconate-6-semialdehyde + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q8TDX5 | human | - |
Mus musculus | Q8R519 | mouse, ICR strain | - |
Mus musculus ICR | Q8R519 | mouse, ICR strain | - |
Rattus norvegicus | Q8R5M5 | rat | - |
Sus scrofa | - |
pig | - |
Purification (Comment) | Organism |
---|---|
- |
Sus scrofa |
- |
Mus musculus |
- |
Rattus norvegicus |
partial | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate | - |
Sus scrofa | 2-aminomuconate-6-semialdehyde + CO2 | - |
? | |
2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate | - |
Mus musculus | 2-aminomuconate-6-semialdehyde + CO2 | - |
? | |
2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate | - |
Rattus norvegicus | 2-aminomuconate-6-semialdehyde + CO2 | - |
? | |
2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate | - |
Homo sapiens | 2-aminomuconate-6-semialdehyde + CO2 | - |
? | |
2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate | tryptophan-niacine pathway | Sus scrofa | 2-aminomuconate-6-semialdehyde + CO2 | - |
? | |
2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate | tryptophan-niacine pathway | Mus musculus | 2-aminomuconate-6-semialdehyde + CO2 | - |
? | |
2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate | tryptophan-niacine pathway | Rattus norvegicus | 2-aminomuconate-6-semialdehyde + CO2 | - |
? | |
2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate | tryptophan-niacine pathway | Homo sapiens | 2-aminomuconate-6-semialdehyde + CO2 | - |
? | |
2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate | - |
Mus musculus ICR | 2-aminomuconate-6-semialdehyde + CO2 | - |
? | |
2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate | tryptophan-niacine pathway | Mus musculus ICR | 2-aminomuconate-6-semialdehyde + CO2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ACMSD | - |
Sus scrofa |
ACMSD | - |
Mus musculus |
ACMSD | - |
Rattus norvegicus |
ACMSD | - |
Homo sapiens |