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Literature summary for 4.1.1.37 extracted from

  • Yip, K.W.; Zhang, Z.; Sakemura-Nakatsugawa, N.; Huang, J.W.; Vu, N.M.; Chiang, Y.K.; Lin, C.L.; Kwan, J.Y.; Yue, S.; Jitkova, Y.; To, T.; Zahedi, P.; Pai, E.F.; Schimmer, A.D.; Lovell, J.F.; Sessler, J.L.; Liu, F.F.
    A porphodimethene chemical inhibitor of uroporphyrinogen decarboxylase (2014), PLoS ONE, 9, e89889.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21-RIL(DE3) cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information not inhibited by acebutulol, naproxen, verapramil, and furosemide Homo sapiens
PI-16
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Uroporphyrinogen III Homo sapiens
-
 Coproporphyrinogen III + 4 CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P06132
-
-

Purification (Commentary)

Purification (Comment) Organism
Ni-NTA column chromatography and gel filtration Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Uroporphyrinogen III
-
 Homo sapiens Coproporphyrinogen III + 4 CO2
-
 ?

Synonyms

Synonyms Comment Organism
UroD
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0099
-
 in 0.1 M Tris, pH 7.7, 7.5 mM dithiothreitol, at 37°C` Homo sapiens PI-16

General Information

General Information Comment Organism
malfunction humans deficient in UROD present with porphyria cutanea tarda, a condition characterized by light-sensitive dermatitis, excretion of excess uroporphyrins, and associated hepatic porphyrin accumulation Homo sapiens