Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2,2'-dipyridyl disulfide | - |
Bos taurus | |
5,5'-dithiobis(2-nitrobenzoate) | - |
Bos taurus | |
Al3+ | - |
Bos taurus | |
Co2+ | - |
Bos taurus | |
Cu2+ | - |
Bos taurus | |
Fe2+ | - |
Bos taurus | |
iodoacetamide | - |
Bos taurus | |
Pb2+ | - |
Bos taurus | |
Zn2+ | - |
Bos taurus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00042 | - |
6-COOH-porphyrinogen I | - |
Bos taurus | |
0.00043 | - |
5-COOH-porphyrinogen III | - |
Bos taurus | |
0.00044 | - |
7-COOH-porphyrinogen I | - |
Bos taurus | |
0.00064 | - |
6-COOH-porphyrinogen III | - |
Bos taurus | |
0.00079 | - |
8-COOH-porphyrinogen I | - |
Bos taurus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Bos taurus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Bos taurus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.016 | - |
- |
Bos taurus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5-COOH-porphyrinogen III | - |
Bos taurus | Coproporphyrinogen III + CO2 | - |
? | |
6-COOH-porphyrinogen I | - |
Bos taurus | Coproporphyrinogen I + CO2 | - |
? | |
6-COOH-porphyrinogen III | - |
Bos taurus | Coproporphyrinogen III + CO2 | - |
? | |
7-COOH-porphyrinogen I | - |
Bos taurus | Coproporphyrinogen I + CO2 | - |
? | |
8-COOH-porphyrinogen I | - |
Bos taurus | Coproporphyrinogen I + CO2 | - |
? | |
additional information | - |
Bos taurus | additional information | the pattern of accumulation of intermediate 7-COOH-porphyrinogens, 6-COOH-porphyrinogens and 5-COOH-porphyrinogens and final coproporphyrinogen decarboxylation products is affected by the ratio of substrate concentration of uroporphyrinogen I or II to enzyme concentration. Under physiological conditions, where the uroporphyrinogen to enzyme ratio is low, the substrate is nearly quantitatively decarboxylated, and the major product is coproporphyrinogen | ? | |
uroporphyrinogen I | - |
Bos taurus | coproporphyrinogen I + 4 CO2 | - |
? | |
Uroporphyrinogen III | - |
Bos taurus | Coproporphyrinogen III + 4 CO2 | - |
? |