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Literature summary for 4.1.1.36 extracted from

  • Ruiz, A.; Gonzalez, A.; Munoz, I.; Serrano, R.; Abrie, J.A.; Strauss, E.; Arino, J.
    Moonlighting proteins Hal3 and Vhs3 form a heteromeric PPCDC with Ykl088w in yeast CoA biosynthesis (2009), Nat. Chem. Biol., 5, 920-928.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
Hal3, Vhs3 and Ykl088w proteins are expressed in Escherichia coli as GST fusion proteins Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
N-[(R)-4'-phosphopantothenoyl]-L-cysteine Saccharomyces cerevisiae
-
pantotheine 4'-phosphate + CO2
-
?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-[(R)-4'-phosphopantothenoyl]-L-cysteine
-
Saccharomyces cerevisiae pantotheine 4'-phosphate + CO2
-
?

Subunits

Subunits Comment Organism
heterotrimer consists of Ykl088w and Hal3/Vhs3 monomers that separately provide two essential catalytic residues Saccharomyces cerevisiae

Synonyms

Synonyms Comment Organism
Phosphopantothenoylcysteine decarboxylase
-
Saccharomyces cerevisiae
PPCDC
-
Saccharomyces cerevisiae

General Information

General Information Comment Organism
physiological function Hal3 and Vhs3 as moonlighting proteins involved in both CoA biosynthesis and protein phosphatase regulation Saccharomyces cerevisiae